Article first published online: 4 FEB 2003
International Journal of Dermatology
Volume 42, Issue 1, pages 31–35, January 2003
How to Cite
Pomann, J. J. and Rudner, E. J. (2003), Scleromyxedema revisited. International Journal of Dermatology, 42: 31–35. doi: 10.1046/j.1365-4362.2003.01565.x
- Issue published online: 4 FEB 2003
- Article first published online: 4 FEB 2003
Scleromyxedema is a rare disease characterized by papular mucinous deposits, dermal fibroblast proliferation, and a monoclonal paraproteinemia. Its chronic course tends to be complicated by gastrointestinal, muscular, pulmonary, and neurologic disorders. We review the literature to identify the common systemic manifestations and suggest a clinical approach to this disorder. This should include: identification of the characteristic lesions, a skin biopsy, and serum protein electrophoresis. A thyroid evaluation may help differentiate this condition from others. An early neurologic, gastrointestinal, and cardiovascular evaluation should be considered.