Scleromyxedema revisited

Authors


Earl J. Rudner, Henry Ford Hospital Dermatology Clinic k-16 2799 West Grand Boulervard, Detroit, MI 48202, USA. Tel: (313)916-2164 Fax: (313)916-2093 Email: erudner1@hfhs.org

Abstract

Scleromyxedema is a rare disease characterized by papular mucinous deposits, dermal fibroblast proliferation, and a monoclonal paraproteinemia. Its chronic course tends to be complicated by gastrointestinal, muscular, pulmonary, and neurologic disorders. We review the literature to identify the common systemic manifestations and suggest a clinical approach to this disorder. This should include: identification of the characteristic lesions, a skin biopsy, and serum protein electrophoresis. A thyroid evaluation may help differentiate this condition from others. An early neurologic, gastrointestinal, and cardiovascular evaluation should be considered.

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