• 1
    Bigby M, Jick S, Jick H, Arndt K. Drug-induced cutaneous reactions: a report from the Boston Collaborative Drug Surveillance Program on 15 438 consecutive inpatients, 1975–1982. JAMA 1986;256: 33583363.
  • 2
    Leape LL, Brennan TA, Laird N, Lawthers AG, Localio AR, Barnes BA et al. The nature of adverse events in hospitalized patients: results of the Harvard Medical Practice Study II. N Engl J Med 1991;324: 377384.
  • 3
    Hunziker TH, Künzi UP, Braunschweig S, Zehnder D, Hoigne R. Comprehensive-hospital drug monitoring (CHDM): adverse skin reactions, a 20-year survey. Allergy 1997;52: 388393.
  • 4
    Barbaud A, Goncalo M, Bruynzeel D, Bircher A. Guidelines for performing skin tests with drugs in the investigation of cutaneous adverse drug reactions. Contact Dermatitis 2001;45: 321328.
  • 5
    Terrados S, Blanca M, Garcia J, Vega JM, Torres MJ, Carmona MJ et al. Non-immediate reactions to betalactams: prevalence and role of the different penicillins. Allergy 1995;50: 563567.
  • 6
    Romano A, Di Fonso M, Papa G, Pietroantonio F, Federico F, Fabrizi G et al. Evaluation of adverse cutaneous reactions to aminopenicillins with emphasis on those manifested by maculopapular rashes. Allergy 1995;50: 113118.
  • 7
    Patriarca F, D'Ambrosio C, Schiviano D, Larocca LM, Nucer E, Milano A. Clinical usefulness of patch and challenge test in the diagnosis of cell-mediated allergy to B-lactams. Ann Allergy Asthma Immunol 1999;83: 257266.
  • 8
    Barbaud AM, Bene MC. Immunological physiopathology of cutaneous adverse drug reactions. Eur J Dermatol 1997;7: 319323.
  • 9
    Pichler WJ, Schneyder B, Zanni M, Hari Y, van Greyerz S. Role of T cells in drug allergies. Allergy 1998;53: 225232.
  • 10
    Barboud A, Reichert-Penetrat S, Tréchot P, Jacquin-Petit MA, Ehlinger A, Noirez V et al. The use of skin testing in the investigation of cutaneous adverse drug reactions. Br J Dermatol 1998;139: 4958.
  • 11
    Warrington RJ, Silviu-Dan F, Magro C. Accelerated cell-mediated immune reactions in penicillin allergy. J Allergy Clin Immunol 1993;92: 626628.
  • 12
    Yamalkar N, Hari Y, Frutig K, Egli F, Wendland T, Braathan LR et al. T cells isolated from positive epicutaneous test reactions to amoxicillin and ceftriaxone are drug specific and cytotoxic. J Invest Dermatol 2000;115: 647652.
  • 13
    Hertl M, Geisel J, Boecker C, Merk HF. Selective generation of CD8+ T-cell clones from the peripheral blood of patients with cutaneous reactions to beta-lactam antibiotics. Br J Dermatol 1993;128: 619626.
  • 14
    Hertl M, Bohlen H, Jugert F, Boecker C, Knaup R, Merk HF. Predominance of epidermal CD8+ lymphocytes in bullous cutaneous reactions caused by betalactams antibiotics. J Invest Dermatol 1993;101: 794799.
  • 15
    Levine BB. Immunologic mechanisms of penicillin allergy. A haptenic model system for the study of allergic diseases of man. N Engl J Med 1966;275: 11151125.
  • 16
    Moller NE, Jeppesen K. Patch testing with semisynthetic penicillins. Contact Dermatitis 1987;16: 227228.
  • 17
    MartÍn JA, Alonso MD, Lázaro M, Parra F, Compaired JA, Alvarez-Cuesta E. Delayed allergic reaction to cefonicid. Ann Allergy 1994;72: 341342.
  • 18
    Osawa J, Naito S, Aihara M, Kitamura K, Ikezawa Z, Nakajima H. Evaluation of skin test reactions in patients with non-immediate type drug eruptions. J Dermatol 1990;17: 235239.
  • 19
    Romano A, Quarantino D, Di Fonso M, Papa G, Venuti A, Gasbarrini G. A diagnostic protocol for evaluating non-immediate reactions to aminopenicillins. J Allergy Clin Immunol 1999;103: 11861190.
  • 20
    Lisi P, Lapomarda U, Stingeni L, Assalve D, Hansel K, Caraffini S et al. Skin test in the diagnosis of eruptions caused by B-lactam. Contact Dermatitis 1997;37: 151154.
  • 21
    Torres MJ, Romano A, Mayorga C, Moya MC, Guzman AE, Reche M et al. Diagnostic evaluation of a large group of patients with immediate allergy to penicillins: the role of skin testing. Allergy 2001;56: 850856.
  • 22
    Vega JM, Blanca M, Carmona MJ, Garcia J, Claros A, Juarez C et al. Delayed allergic reactions to betalactams. Allergy 1991;46: 154157.
  • 23
    Posadas S, Leyva L, Torres MJ, Rodriguez JL, Bravo I, Rosal M et al. Subjects with allergic reactions to drugs show in vivo polarized patterns of cytokine expression depending on the chronology of the clinical reaction. J Allergy Clin Immunol 2000;106: 769776.
  • 24
    Blanca M, Mayorga C, Torres MJ, Reche M, Moya MC, Rodriguez JL et al. Clinical evaluation of Pharmacia CAP SystemTM RAST FEIA amoxicilloyl and benzylpenicilloyl in patients with penicillin allergy. Allergy 2001;56: 862870.
  • 25
    Wilkinson DS, Fregert S, Magnusson B, Bandmann HJ, Calnan CD, Cronin E et al. Terminology of contact dermatitis. Acta Derm Venereol 1970;50: 287292.
  • 26
    Schnyder B, Helbling A, Kappeler A, Pichler WJ. Drug-induced papulovesicular exanthema. Allergy 1998;53: 817818.