• 1
    Gregg I. Epidemiologic aspects. In: ClarkTJH, GodfreyS, editors. Asthma. London: Chapman and Hall, 1983: 242284.
  • 2
    Hopkin JM. The rise of atopy and links to infection. Allergy 2002;57(Suppl. 72):59.
  • 3
    Asher MI, Pattemore PK, Harrison AC, Mitchell EA, Rea HH, Stewart AW et al. International comparison of the prevalence of asthma symptoms and bronchial hyperresponsiveness. Am Rev Respir Dis 1988;138: 524529.
  • 4
    Cookson JB. Prevalence rates of asthma in developing countries and their comparison with those in Europe and North America. Chest 1987;91(Suppl.):S97103.
  • 5
    Burr ML, Limb ES, Andrae S, Barry DM, Nagel F. Childhood asthma in four countries: a comparative survey. Int J Epidemiol 1994;23: 341347.
  • 6
    Strachan DP. The epidemiology of childhood asthma. Allergy 1999;54: 711.
  • 7
    Beasley R, Keil U, Von Mutius E, Pearce N. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. Lancet 1998;351: 12251232.
  • 8
    Asher MI, Anderson HR, Stewart AW, Crane J. Worldwide variations in the prevalence of asthma symptoms: the International Study of Asthma and Allergies in Childhood (ISAAC) Eur Respir J 1998;12: 315335.
  • 9
    Burney P, Chinn S, Jarvis D, Luczynska C, Lai E. Variation in the prevalence of respiratory symptoms, self-reported asthma attacks, and use of asthma medication in the European Community Respiratory Health Survey (ECRHS). Eur Respir J 1996;9: 687695.
  • 10
    Von Mutius E, Martinez FD, Fritzsch C, Nicolai T, Roell G, Thiemann HH. Prevalence of asthma and atopy in two areas of West and East Germany. Am J Respir Crit Care Med 1994;149: 358364.
  • 11
    Von Mutius E, Fritzsch C, Weiland SK, Roell G, Magnussen H. Prevalence of asthma and allergic disorders among children in united Germany: a descriptive comparison. BMJ 1992;305: 13951399.
  • 12
    Nicolai T, Bellach B, von Mutius E, Thefeld W, Hoffmeister H. Increased prevalence of sensitization against aeroallergens in adults in West compared with East Germany. Clin Exp Allergy 1997;27: 886892.
  • 13
    Bråbäck L, Breborowicz A, Dreborg S, Knutsson A, Pieklik H, Björksten B. Atopic sensitization and respiratory symptoms among Polish and Swedish schoolchildren. Clin Exp Allergy 1994;24: 826835.
  • 14
    Jögi R, Janson C, Björnsson E, Boman G, Björksten B. The prevalence of asthmatic respiratory symptoms among adults in Estonia and Swedish university cities. Allergy 1996;51: 331336.
  • 15
    Vartiainen E, Petäys T, Haahtela T, Jousilahti P, Pekkanen J. Allergic diseases, skin prick test and immunoglobulin E levels in North Karelia, Finland and in Karelia Republic, Russia. J Allergy Clin Immunol 2002;109: 643648.
  • 16
    Bråbäck L, Breborowics A, Julge K, Knutsson A, Riikjärv MA, Vasar M et al. Risk factors for respiratory symptoms and atopic sensitisation in the Baltic area. Arch Dis Chlidhood 1995;72: 487493.
  • 17
    Björksten B, Dumitrascu D, Foucard T, Khetsuriani N, Khaitov R, Leja M et al. Prevalence of childhood asthma, rhinitis and eczema in Scandinavia and Eastern Europe. Eur Respir J 1998;12: 432437.
  • 18
    Morrison Smith J, Harding LK, Cumming G. The changing prevalence of asthma in school children. Clin Allergy 1971;1: 5761.
  • 19
    Waite DA, Egles EF, Tonkin SL, O'Donnell TU. Asthma prevalence in Tokelauan children in two environments. Clin Allergy 1980;10: 7175.
  • 20
    Kalyoncu AF, Stålenheim G. Serum IgE levels and allergic spectra in immigrants to Sweden. Allergy 1992;47: 277280.
  • 21
    Matricardi PM. Infections preventing atopy: facts and new questions. Allergy 1997;52: 879882.
  • 22
    Van Niekerk CH, Weinberg EG, Shore SC, Heese HDV, Van Schalkwyk DJ. Prevalence of asthma: a comparative study of urban and rural Xhosa children. Clin Allergy 1979;9: 319324.
  • 23
    Yemaneberhan H, Bekele Z, Venn A, Lewis S, Parry E, Britton J. Prevalence of wheeze and asthma and relation to atopy in urban and rural Ethiopia. Lancet 1997;350: 8590.
  • 24
    Addo Yobo EOD, Custovic A, Taggart S, Asafo-Agyei AP, Woodcock A. Exercise induced bronchospasm in Ghana: differences in prevalence between urban and rural schoolchildren. Thorax 1997;52: 161165.
  • 25
    Bråbäck L, Kälvesten L. Urban living as a risk factor for atopic sensitization in Swedish schoolchildren. Pediatr Allergy Immunol 1991;2: 1419.
  • 26
    Leung R, Ho P. Asthma, allergy, and atopy in three south-east Asia populations. Thorax 1994;49: 12051210.
  • 27
    Bousquet J, Ndiaye M, Aït-Khaled N, Annesi-Maesano I, Vignola A-M. Management of chronic respiratory and allergic diseases in developing countries. Focus on sub-Saharan Africa. Allergy 2003;58: 265283.
  • 28
    Holt PG, Sly PD, Björksten B. Atopic versus infectious diseases in childhood: a question of balance? Pediatr Allergy Immunol 1997;8: 5358.
  • 29
    Wjst M, Reitmeir P, Dold S, Wulff A, Nicolai T, Von Loeffelholz-Colberg E et al. Road traffic and adverse effects on respiratory health in children. BMJ 1993;307: 596600.
  • 30
    von Mutius E, Illi S, Nicolai T, Martinez F. Relation of indoor heating with asthma, allergic sensitization, and bronchial responsiveness. BMJ 1996;312: 14481450.
  • 31
    Nicolai T. Asthma prevalence: lessons from the reunification of Germany. Clin Asthma Rev 1997;1: 16.
  • 32
    Haahtela T, Lindholm H, Björksten F, Koskenvuo K, Laitinen LA. Prevalence of asthma in Finnish young men. BMJ 1990;301: 266268.
  • 33
    Wichmann HE. Possible explanation for the different trends of asthma and allergy in east and west Germany. Clin Exp Allergy 1996;26: 621623.
  • 34
    Von Mutius E. The environmental predictors of allergic diseases. J Allergy Clin Immunol 2000;105: 919.
  • 35
    Karmaus W, Botezan C. Does a higher number of siblings protect against the development of allergy and asthma? A review. J Epidemiol Community Health 2002;56: 209217.
  • 36
    Von Mutius E. Infection: friend or foe in the development of atopy and asthma? Eur Respir J 2001;18: 872881.
  • 37
    Strachan DP. Lifestyle and atopy. Lancet 1999;353: 14571458.
  • 38
    Karmaus W, Arshad H, Mattes J. The sibling effect may have its origin in utero. An investigation into birth order, cord-blood IgE concentration, and allergic sensitization at age four. Am J Epidemiol 2001;154: 909915.
  • 39
    Von Hertzen LC. Maternal stress and T-cell differentiation of the developing immune system: possible implications for the development of asthma and atopy. J Allergy Clin Immunol 2002;109: 923928.
  • 40
    Annesi-Maesano I, Pollitt R, King G, Bousquet J, Hellier G, Sahuquillo J et al. In utero exposure to lead and cord blood total IgE. Is there a connection? Allergy 2003;58: 589594.
  • 41
    Krämer U, Heinrich J, Wjst M, Wichmann HE. Age of entry to day nursery and allergy in later childhood. Lancet 1998;353: 450454.
  • 42
    Ball TM, Castro-Rodrigues JA, Griffith KA, Holberg CJ, Martinez FD, Wright AL. Siblings, day-care attendance, and the risk of asthma and wheezing during childhood. N Engl J Med 2000;343: 538543.
  • 43
    Nystad W. Daycare attendance, asthma and atopy. Ann Med 2000;32: 390396.
  • 44
    Barker DJP. Fetal and infant origins of adult disease. London: BMJ Publishing, 1992.
  • 45
    Strachan DP. Hay fever, hygiene, and household size. BMJ 1989;299: 12591260.
  • 46
    Martinez FD. Role of viral infections in the inception of asthma and allergies during childhood: could they be protective? Thorax 1994;49: 11891191.
  • 47
    Holt PG. Environmental factors and primary T-cell sensitisation to inhalant allergens: reappraisal of the role of infections and air pollution. Pediatr Allergy Immunol 1995;6: 110.
  • 48
    Lewis S. ISAAC – a hypothesis generator for asthma? Lancet 1998;351: 12201221.
  • 49
    Holt PG, Sly PD. Interactions between respiratory tract infections and atopy in the aetiology of asthma. Eur Respir J 2002;19: 538545.
  • 50
    Renz H, Herz U. The bidirectional capacity of bacterial antigens to modulate allergy and asthma. Eur Respir J 2002;19: 158171.
  • 51
    Von Hertzen LC, Haahtela T. Could the risk of asthma and atopy be reduced by a vaccine that induces a strong T-helper type 1 response? Am J Respir Cell Molec Biol 2000;22: 139142.
  • 52
    Martinez FD, Holt PG. Role of microbial burden in aetiology of allergy and asthma. Lancet 1999;354(Suppl. II):SII1215.
  • 53
    Martinez FD. Maturation of immune responses at the beginning of asthma. J Allergy Clin Immunol 1999;103: 355361.
  • 54
    Yazdanbakhsh M, Kremsner PG, Van Ree R. Allergy, parasites and the hygiene hypothesis. Science 2002;296: 490494.
  • 55
    Herz U, Gerhold K, Gruber C, Braun A, Wahn U, Renz H et al. BCG infection suppresses allergic sensitization and development of increased airway reactivity in an animal model. J Allergy Clin Immunol 1998;102: 867874.
  • 56
    Erb KJ, Holloway JW, Sobeck A, Moll H, LeGros G. Infection of mice with Mycobacterium bovis-Bacillus Calmette-Guerin (BCG) suppresses allergen-induced airway eosinophilia. J Exp Med 1998;187: 561569.
  • 57
    Wang CC, Rook GA. Inhibition of an established allergic response to ovalbumin in BALB/c mice by killed Mycobacterium vaccae. Immunology 1998;93: 307313.
  • 58
    Hopfenspirger MT, Parr SK, Hopp RJ, Townley RG, Agrawal DK. Mycobacterial antigens attenuate late phase response, airway hyperresponsiveness, and bronchoalveolar lavage eosinophilia in a mouse model of bronchial asthma. Int Immunopharmacol 2001;1: 17431751.
  • 59
    Shaheen SO, Aaby P, Hall AJ, Barker DJ, Heyes CB, Shiell AW et al. Measles and atopy in Guinea-Bissau. Lancet 1996;347: 17921796.
  • 60
    Matricardi PM, Rosmini F, Ferrigno L, Nisini R, Rapicetta M, Chionne P et al. Cross-sectional retrospective study of prevalence of atopy among Italian military students with antibodies against hepatitis A virus. BMJ 1997;314: 9991003.
  • 61
    Shirakawa T, Enomoto T, Shimazu S, Hopkin JM. The inverse association between tuberculin responses and atopic disorder. Science 1997;275: 7779.
  • 62
    Von Mutius E, Pearce N, Beasley R, Cheng S, von Ehrenstein O, Björksetn B et al. International patterns of tuberculosis and the prevalence of symptoms of asthma, rhinitis, and eczema. Thorax 2000;55: 449453.
  • 63
    von Hertzen L, Klaukka T, Mattila H, Haahtela T. Mycobacterium tuberculosis infection and the subsequent development asthma and allergic conditions. J Allergy Clin Immunol 1999;104: 12111214.
  • 64
    Kosunen TU, Höök-Nikanne J, Salomaa A, Sarnas S, Aromaa A, Haahtela T. Increase of allergen-specific immunoglobulin E antibodies from 1973 to 1994 in a Finnish population and a possible relationship to Helicobacter pylori infections. Clin Exp Allergy 2002;32: 373378.
  • 65
    Zevering Y. Vaccine against Helicobacter pylori? Ann Med 2001;33: 156166.
  • 66
    Blaser MJ. Helicobacters are indigenous to the human stomach: duodenal ulceration is due to changes in gastric microecology in the modern era. Gut 1998;43: 721727.
  • 67
    Blaser MJ. Hypothesis: the changing relationship of Helicobacter pylori and humans: implications for health and disease. J Infect Dis 1999;179: 15231530.
  • 68
    Matricardi PM, Rosmini P, Riondino S, Fortini M, Ferrigno L, Rapicetta M et al. Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: epidemiological study. BMJ 2000;320: 412417.
  • 69
    Matricardi PM, Rosmini F, Panetta V, Ferrigno L, Bonini S. Hay fever and asthma in relation to markers of infection in the United States. J Allergy Clin Immunol 2002;110: 381387.
  • 70
    Linneberg A, Ostergaard C, Tvede M, Andersen LP, Nielsen NH, Madsen F et al. IgG antibodies against micro-organisms and atopic disease in Danish adults: The Copenhagen Allergy Study. J Allergy Clin Immunol 2003;111: 847853.
  • 71
    Gerrard JW, Geddes CA, Gerrard CD, Horne S. Serum IgE levels in white and metis communities in Saskatchewan. Ann Allergy 1976;37: 91100.
  • 72
    Anderson HR. Respiratory abnormalities in Papua New Guinea children: the effects of locality and domestic wood smoke pollution. Int J Epidemiol 1978;7: 6372.
  • 73
    Mantle J, Pepys J. Asthma among Tristan da Cunha islanders. Clin Allergy 1974;4: 161170.
  • 74
    Samuels N. Experiences of a medical officer on Tristan da Cunha, June–October 1961. BMJ 1963;ii: 10131017.
  • 75
    Tyrrell DAJ, Peto M, King N. Serological studies on infections by respiratory viruses of the inhabitants of Tristan da Cunha. J Hyg 1967;65: 327341.
  • 76
    Brown P, Gajdusek DC, Morris JA. Epidemic A2 influenza in isolated Pacific Island populations without pre-epidemic antibody to influenza virus type A and B, and the discovery of other still unexposed populations. Am J Epidemiol 1966;83: 176188.
  • 77
    Brown P, Gajdusek DC. Acute and chronic pulmonary airway disease in Pacific Island Micronesians. Am J Epidemiol 1978;108: 266273.
  • 78
    Flynn MGL. Respiratory symptoms, bronchial responsiveness, and atopy in Fijian and Indian children. Am J Respir Crit Care Med 1994;150: 415420.
  • 79
    Flynn MGL. Respiratory symptoms of rural Fijian and Indian children in Fiji. Thorax 1994;49: 12011204.
  • 80
    Illi S, Von Mutius E, Lau S, Bergmann R, Niggemann B, Sommerfeld C et al. Early childhood infectious diseases and the development of asthma up to school age: a birth cohort study. BMJ 2001;322: 390395.
  • 81
    Kilpi T, Kero J, Jokinen J, Syrjänen R, Takala AK, Hovi T et al. Common respiratory infections early in life may reduce the risk of atopic dermatitis. Clin Infect Dis 2002;34: 620626.
  • 82
    Uter W, Stock C, Pfahlberg A, Guillén-Grima F, Aguinaga-Ontoso I, Brun-Sandiumenge C et al. Association between infections and signs and symptoms of ‘atopic’ hypersensitivity – results of a cross-sectional survey among first-year university students in Germany and Spain. Allergy 2003;58: 580584.
  • 83
    Paunio M, Heinonen OP, Virtanen M, Leinikki P, Patja A, Peltola H. Measles history and atopic diseases. JAMA 2000;283: 343346.
  • 84
    Bodner C, Godden D, Seaton A. Family size, childhood infections and atopic diseases. The Aberdeen WHEASE Group. Thorax 1998;53: 2832.
  • 85
    Farooqi IS, Hopkin JM. Early childhood infection and atopic disorder. Thorax 1998;53: 927932.
  • 86
    Strannegård IL, Larsson LO, Wennergren G, Strannegård Ö. Prevalence of allergy in children in relation to prior BCG vaccination and infection with atypical mycobacteria. Allergy 1998;53: 249254.
  • 87
    Remes S, Mäkelä M, Marshall J. Measles and atopy in Finland. Allergy 2000;55: 973974.
  • 88
    Yeung VP, Gieni RS, Umetsu DT, DeKruyff RH. Heat-killed Listeria monocytogenes as an adjuvant converts established murine Th2-dominated immune responses into Th1-dominated responses. J Immunol 1998;161: 41464152.
  • 89
    Murosaki S, Yamamoto Y, Ito K, Inokuchi T, Kusaka H, Ikeda H et al. Heat-killed Lactobacillus plantarum L-137 suppresses naturally fed antigen-specific IgE production by stimulation of IL-12 production in mice. J Allergy Clin Immunol 1998;102: 5764.
  • 90
    D'Andrea A, Rengaraju M, Valiante NM, Chehimi J, Kubin M, Aste M et al. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J Exp Med 1992;176: 13871398.
  • 91
    Le J, Lin JX, Henriksen-Destefano D, Vilcek J. Bacterial lipopolysaccharide-induced interferon-gamma production: roles of interleukin 1 and interleukin 2 J Immunol 1986;136: 45254530.
  • 92
    Liu AH. Endotoxin-exposure in allergy and asthma: reconciling a paradox. J Allergy Clin Immunol 2002;109: 379392.
  • 93
    Gereda JE, Leung DY, Thatayatikom A, Streib JE, Price MR, Klinnert MD et al. Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma. Lancet 2000;355: 16801683.
  • 94
    Gehring U, Bolte G, Borte M, Bischof W, Fahlbusch B, Wichmann HE et al. Exposure to endotoxin decreases the risk of atopic eczema in infancy: a cohort study. J Allergy Clin Immunol 2001;108: 847854.
  • 95
    Von Mutius E, Braun-Fahrländer C, Schierl R, Riedler J, Ehlermann S, Maisch S et al. Exposure to endotoxin or other bacterial components might protect against the development of atopy. Clin Exp Allergy 2000;30: 12301234.
  • 96
    Braun-Fahrländer C, Riedler J, Herz U, Eder W, Waser M, Grize L et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med 2002;347: 869877.
  • 97
    Bolte G, Bischof W, Borte M, Lehmann I, Wichmann HE, Heinrich J. Early endotoxin exposure and atopy development in infants: results of a birth cohort study. Clin Exp Allergy 2003;33: 770776.
  • 98
    Mestecky J. The common mucosal immune system and current strategies for induction of immune responses in external secretions. J Clin Immunol 1987;7: 265276.
  • 99
    Matricardi PM, Bonini S. High microbial turnover rate preventing atopy: a solution to inconsistencies impinging on the hygiene hypothesis? Clin Exp Allergy 2000;30: 15061510.
  • 100
    Adlerberth I, Carlsson B, De Man P, Wold A. Intestinal colonization with Enterobacteriacae in Pakistani and Swedish hospital-delivered infants. Acta Paediatr Scand 1991;80: 602610.
  • 101
    Sepp E, Julge V, Vasar M, Naaber P, Björksten B, Mikelsaar M. Intestinal microflora of estonian and Swedish infants. Acta Paediatr 1997;86: 956961.
  • 102
    Björksten B, Naaber P, Sepp E, Mikelsaar M. The intestinal microflora in allergic Estonian and Swedish 2-year-old children. Clin Exp Allergy 1999;29: 342346.
  • 103
    Björksten B, Sepp E, Julge K, Voor T, Mikelsaar M. Allergy development and the intestinal microflora during the first year of life. J Allergy Clin Immunol 2001;108: 516520.
  • 104
    Lundequist B, Nord C, Winberg J. The composition of fecal microflora in breast-fed and bottle-fed infants from birth to eight weeks. Acta Paediatr Scand 1985;71: 4551.
  • 105
    Salminen S, Isolauri E, Onnela T. Gut flora in normal and disordered states. Chemotherapy 1995;41(Suppl. 1):515.
  • 106
    Miettinen M, Matikainen S, Vuopio-Varkila J, Pirhonen J, Varkila K, Kurimoto M et al. Lactobacilli and streptococci induce interleukin-12 (IL-12), IL-18, and gamma-interferon production in human peripheral blood mononuclear cells. Infect Immun 1998;66: 60586062.
  • 107
    Van Vlem B, Vanholder R, De Paepe P, Vogelaers D, Ringoir S. Immunomodulatory effects of antibiotics. Infection 1996;24: 275291.
  • 108
    McKeever TM, Lewis SA, Smith C, Collins J, Heatlie H, Frischer M et al. Early exposure to infections and antibiotics and the incidence of allergic diseases. A birth cohort study with the West Midlands General Practice Research Database. J Allergy Clin Immunol 2002;109: 4350.
  • 109
    Wickens K, Pearce N, Crane J, Beasley R. Antibiotic use in early childhood and the development of asthma. Clin Exp Allergy 1999;29: 766771.
  • 110
    Droste JHJ, Wieringa MH, Weyler JJ, Nelen VJ, Vermeire PA, Van Bever HP. Does the use of antibiotics in early childhood increase the risk of asthma and allergic disease? Clin Exp Allergy 2000;30: 15471553.
  • 111
    Alm JS, Swartz J, Lilja G, Scheynius A, Pershagen G. Atopy in children of families with an anthroposophic lifestyle. Lancet 1999;353: 14851488.
  • 112
    Von Mutius E, Illi S, Hirsch T, Leupold W, Keil U, Weiland SK. Frequency of infections and risk of asthma, atopy and airway hyperresponsiveness in children. Eur Respir J 1999;14: 411.
  • 113
    Celedon JC, Litonjua AA, Ryan L, Weiss ST, Gold DR. Lack of association between antibiotic use in the first years of life and asthma, allergic rhinitis or eczema at age 5 years Am J Respir Crit Care Med 2002;166: 7275.
  • 114
    Braun-Fahrländer C, Gassner M, Grize L, Neu U, Sennhauser FH, Varonier HS et al. Prevalence of hay fever and allergic sensitization in farmer's children and their peers living in the same rural community. Clin Exp Allergy 1999;29: 2834.
  • 115
    Von Ehrenstein O, Von Mutius E, Illi S, Bauman L, Böhm O, Von Kries R. Reduced risk of hay fever and asthma among children of farmers. Clin Exp Allergy 2000;30: 187193.
  • 116
    Riedler J, Eder W, Oberfeld G, Schreuer M. Austrian children living on a farm have less hay fever, asthma and allergic sensitisation. Clin Exp Allergy 2000;30: 194200.
  • 117
    Horak F Jr, Studnicka M, Gartner C, Veiter A, Tauber E, Urbanek R et al. Parental farming protects children against atopy: longitudinal evidence involving skin prick tests. Clin Exp Allergy 2002;32: 11551159.
  • 118
    Kilpeläinen M, Terho EO, Helenius H, Koskenvuo M. Farm environment in childhood prevents the development of allergies. Clin Exp Allergy 2000;30: 201208.
  • 119
    Portengen L, Sigsgaard T, Omland O, Hjort C, Heederik D, Doekes G. Low prevalence of atopy in young Danish farmers and farming students born and raised on a farm. Clin Exp Allergy 2002;32: 247253.
  • 120
    Ernst P, Cormier Y. Relative scarcity of asthma and atopy among rural adolescents raised on a farm. Am J Respir Crit Care Med 2000;161: 15631566.
  • 121
    Kauffmann F, Oryszczyn P, Maccario J. The protective role of country living on skin prick tests, immunoglobulin E and asthma in adults from the epidemiological study on the genetics and environment of asthma, bronchial hyper-responsiveness and atopy. Clin Exp Allergy 2002;32: 379386.
  • 122
    Wickens K, Lane JM, Fitzharris P, Siebers R, Riley G, Douwes J et al. Farm residence and exposures and the risk of allergic diseases in New Zealand children. Allergy 2003;57: 11711179.
  • 123
    Hasselmar B, Åberg N, Åberg B, Eriksson B, Björksten B. Does early exposure to cat or dog protect against later allergy development? Clin Exp Allergy 1999;29: 611617.
  • 124
    Ownby DR, Johnson CC, Peterson EL. Exposure to dogs and cats in the first year of life and risk of allergic sensitization at 6 to 7 years of age. JAMA 2002;288: 963972.
  • 125
    Celedon JC, Litonjua AA, Ryan L, Platts-Mills T, Weiss ST, Gold DR. Exposure to cat allergen, maternal history of asthma, and wheezing in first 5 years of life. Lancet 2002;360: 781782.
  • 126
    Perzanowski MS, Rönmark E, Platts-Mills TAE, Lundbäck B. Effect of cat and dog ownership on sensitization and development of asthma among preteenage children. Am J Respir Crit Care Med 2002;166: 696702.
  • 127
    Cooper PJ. Can intestinal helminth infections (geohelminths) affect the development and expression of asthma and allergic diseases? Clin Exp Immunol 2002;128: 398404.
  • 128
    Yazdanbakhsh M, Van Den Biggelaar AHJ, Maizels RM. Th2 responses without atopy: immunoregulation in chronic helminth infections and reduced allergic disease. Trends Immunol 2001;22: 372377.
  • 129
    Ring J, Krämer U, Schäfer T, Behrendt H. Why are allergies increasing? Curr Opin Immunol 2001;13: 701708.
  • 130
    Larrick JW, Buckley E, Machamer C, Schlagel GD, Yost JA, Blessing-Moore J et al. Does hyperimmunoglobulinemia-E protect tropical populations from allergic disease? J Allergy Clin Immunol 1983;71: 184188.
  • 131
    Behrendt H, Krämer U, Dolgner R, Hinrichs J, Willer H, Hagenbeck H et al. Elevated levels of total serum IgE in East German children: atopy, parasites, or pollutants? Allergo J 1993;2: 3140.
  • 132
    Hagel I, Lynch NR, Perez M, Di Prisco MC, Lopez R, Rojas E. Modulation of the allergic reactivity of slum children by helminthic infection. Parasite Immunol 1993;15: 311315.
  • 133
    Lynch NR, Hagel I, Perez M, Di Prisco MC, Lopez R, Alvarez N. Effect of antihelmintic treatment on the allergic reactivity of children in a tropical slum. J Allergy Clin Immunol 1993;92: 404411.
  • 134
    Van Den Biggelaar AH, Van Ree R, Rodrigues LC, Lell B, Deelder AM, Kremsner PG et al. Decreased atopy in children infected with Schistosoma haematobium: a role for parasite- induced interleukin-10. Lancet 2000;356: 17231727.
  • 135
    Scrivener S, Yemaneberhan H, Zebenigus M, Tilahun D, Girma S, Ali S et al. Independent effects of intestinal parasite infection and domestic allergen exposure on risk of wheeze in Ethiopia: a nested case–control study. Lancet 2001;358: 14931499.
  • 136
    Huang SL, Tsai PF, Yeh YF. Negative association of Enterobius infestation with asthma and rhinitis in primary school children in Taipei. Clin Exp Allergy 2002;32: 10291032.
  • 137
    Palmer LJ, Celedon JC, Weiss ST, Wang B, Fang Z, Xu X. Ascaris lumbricoides infection is associated with increased risk of childhood asthma and atopy in rural China. Am J Respir Crit Care Med 2002;165: 14891493.
  • 138
    Dold S, Heinrich J, Wichmann HE, Wjst M. Ascaris-specific IgE and allergic sensitization in a cohort of school children in the former East Germany. J Allergy Clin Immunol 1998;102: 414420.
  • 139
    Flohr C. Dirt, worms and atopic dermatitis. Br J Dermatol 2003;148: 871877.
  • 140
    Zuany-Amorim C, Sawicka E, Manlius C, LeMoine A, Brunet LR, Kemeny DM et al. Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells. Nat Med 2002;8: 625629.
  • 141
    Edwards-Smith CJ, Jonsson JR, Purdie DM, Bansal A, Shorthouse C, Powell EE. Interleukin-10 promoter polymorphism predicts initial response of chronic hepatitis C to interferon alfa. Hepatology 1999;30: 526530.
  • 142
    Umtesu DT, McIntire JJ, Akbari O, Macaubas C, DeKruyff R. Asthma: an epidemic of dysregulated immunity. Nat Immunol 2002;3: 715720.
  • 143
    Gale EAM. A missing link in the hygiene hypothesis? Diabetologia 2002;45: 588594.
  • 144
    Romagnani S. Regulation of the development of type 2 helper cells in allergy. Curr Opin Immunol 1994;6: 838846.
  • 145
    Akbari O, Freeman GJ, Meyer EH, Greenfield EA, Chang TT, Sharpe AH et al. Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat Med 2002;8: 10241032.
  • 146
    Lauener RP, Birchler T, Adamski J, Braun-Fahrländer C, Bufe A, Herz U et al. Expression of CD14 and Toll-like receptor 2 in farmers’ and non-farmers’ children. Lancet 2002;360: 465466.
  • 147
    Holgate ST. The epidemic of asthma and allergy. Nature 1999;402(Suppl.):B24.
  • 148
    Koppelman GH, Los H, Postma DS. Genetic and environment in asthma: the answer of twin studies Eur Respir J 1999;13: 24.
  • 149
    Von Mutius E, Weiland SK, Fritzsch C, Duhme H, Keil U. Increasing prevalence of hay fever and atopy among children in Leipzig, East Germany. Lancet 1998;351: 862866.
  • 150
    Le Souëf PN, Goldblatt J, Lynch NR. Evolutionary adaptation of inflammatory immune responses in human beings. Lancet 2000;356: 242244.
  • 151
    Lester LA, Rich SS, Blumenthal MN, Togias A, Murphy S, Malveaux F et al. Ethnic differences in asthma and associated phenotypes: collaborative study on the genetics of asthma. J Allergy Clin Immunol 2001;108: 357362.
  • 152
    Warner JO. Worldwide variations in the prevalence of atopic symptoms: what does it all mean? Thorax 1999;54(Suppl. 2):S4651.
  • 153
    Cookson W. The alliance of genes and environment in asthma and allergy. Nature 1999;402(Suppl.):B511.
  • 154
    Maloy KJ, Powrie F. Regulatory T cells in the control of immune pathology. Nat Immunol 2001;2: 816822.
  • 155
    Powrie F, Maloy KJ. Regulating the regulators. Science 2003;299: 10301031.
  • 156
    Kalliomäki M, Salminen S, Arvilommi H, Kero P, Koskinen P, Isolauri E. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet 2001;357: 10761079.
  • 157
    Helin T, Haahtela S, Haahtela T. No effect of oral treatment with an intestinal bacterial strain, Lactobacillus rhamnosus (ATCC 53103), on birch-pollen allergy: a placebo-controlled double-blind study. Allergy 2002;57: 243246.
  • 158
    Arkwright PD, David TJ. Intraderman administration of a killed Mycobacterium vaccae suspension (SRL 172) is associated with improvement in atopic dermatitis in children with moderate-to-severe disease. J Allergy Clin Immunol 2001;107: 531534.
  • 159
    Matricardi PN, Björksten B, Bonini S, Bousquet J, Djukanovic R, Dreborg S et al. Microbial products in allergy prevention and therapy. Allergy 2003;58: 461471.