Each author declares that they have no potential conflict of interest.
Prophylactic effect of phenytoin in bipolar disorder: a controlled study
Article first published online: 25 NOV 2003
Volume 5, Issue 6, pages 464–467, December 2003
How to Cite
Mishory, A., Winokur, M. and Bersudsky, Y. (2003), Prophylactic effect of phenytoin in bipolar disorder: a controlled study. Bipolar Disorders, 5: 464–467. doi: 10.1046/j.1399-5618.2003.00070.x
- Issue published online: 25 NOV 2003
- Article first published online: 25 NOV 2003
- Received 5 December 2002, revised and accepted for publication 22 August 2003
- bipolar disorder;
Objective: Phenytoin is an effective anticonvulsant that has not previously been studied prophylactically in bipolar (BP) patients. Thus a study of phenytoin prophylaxis was undertaken and is herein reported.
Method: Bipolar patients were studied who had at least one episode per year in the previous 2 years despite ongoing prophylaxis. Patients were stable for a mean of 4 months (range 1–13) before entering the study. Phenytoin or placebo was added to their current therapy in a double-blind cross-over design for 6 months in each phase. Thirty observation periods of 6 months each were studied for 23 patients.
Results: Three patients had relapse on phenytoin and nine had relapse on placebo. There was a significant prophylactic effect of phenytoin in BP disorder [Cox's F-test for comparing survival in two groups: F(6, 18) = 3.44, p = 0.02].
Conclusions: This study suggests prophylactic effects of add-on phenytoin in BP illness. However, the number of patients was small and confirmation is necessary.