Dialysis of saliva improves accuracy of saliva lithium determinations
Article first published online: 3 FEB 2004
Volume 6, Issue 1, pages 87–89, February 2004
How to Cite
El-Mallakh, R. S., Linder, M., Valdes, R. and Looney, S. (2004), Dialysis of saliva improves accuracy of saliva lithium determinations. Bipolar Disorders, 6: 87–89. doi: 10.1046/j.1399-5618.2003.00080.x
- Issue published online: 3 FEB 2004
- Article first published online: 3 FEB 2004
- Received 7 May 2002, revised and accepted for publication 8 May 2003
- lithium levels;
Background: Saliva lithium (Li) determinations have been explored as a potential alternative to plasma levels. Unfortunately, this method has been shown to be unreliable. Saliva has two major components: the aqueous and the mucopolysaccharide portions.
Methods: Since Li is likely to distribute only in the aqueous fraction, we dialyzed the saliva through a 3000 Da filter to isolate the aqueous component and determine the Li level in it.
Results: Lithium levels in the dialyzed saliva agreed more closely with plasma levels (Spearman's rho = 0.901, p < 0.001) than did whole saliva (Spearman's rho = 0.775, p = 0.012).
Conclusion: Dialysis of saliva may contribute to more accurate saliva Li levels.