A review of antidepressant-induced hypomania in major depression: suggestions for DSM-V
Article first published online: 3 FEB 2004
Volume 6, Issue 1, pages 32–42, February 2004
How to Cite
Chun, B. J. and Dunner, D. L. (2004), A review of antidepressant-induced hypomania in major depression: suggestions for DSM-V. Bipolar Disorders, 6: 32–42. doi: 10.1046/j.1399-5618.2003.00084.x
- Issue published online: 3 FEB 2004
- Article first published online: 3 FEB 2004
- Received 3 March 2003, revised and accepted for publication 21 July 2003
- bipolar disorder;
Objectives: To determine if the classification of ‘antidepressant-induced hypomania’ in DSM-IV is supported by available data.
Methods: We reviewed the available scientific literature to examine the incidence of mania and hypomania in non-bipolar patients who were treated with antidepressants.
Results: Eighty-nine per cent of studies of antidepressants in major depressive disorder patients reported no cases of treatment-induced hypomania. No instances of treatment-induced hypomania were reported in three large studies of patients with chronic forms of depression.
Conclusions: The rate of antidepressant-induced hypomania in major depressive disorder is within the rate of misdiagnosis of bipolar depression as unipolar. Depressed patients who experience antidepressant-associated hypomania are truly bipolar.