Effectiveness of Leukocyte Filters in Reducing Tumor Cell Contamination after Intraoperative Blood Salvage in Lung Cancer Patients
Article first published online: 1 MAY 2003
Volume 72, Issue 4, pages 221–224, June 1997
How to Cite
Perseghin, P., Viganò, M., Rocco, G., Della Pona, C., Buscemi, A. and Rizzi, A. (1997), Effectiveness of Leukocyte Filters in Reducing Tumor Cell Contamination after Intraoperative Blood Salvage in Lung Cancer Patients. Vox Sanguinis, 72: 221–224. doi: 10.1046/j.1423-0410.1997.7240221.x
- Issue published online: 1 MAY 2003
- Article first published online: 1 MAY 2003
Objectives: In an effort to reduce allogeneic blood transfusions in patients undergoing elective surgery for lung cancer, we investigated the effectiveness of a method of processing shed blood with an automated device for intra operative blood salvage (IOBS) and filtration with a 3rd-generation polyester filter to remove tumor cells. Methods: Sixteen patients were operated on for different types of lung cancer. We searched for malignant cells in pre- and postprocessed shed blood employing density gradient centrifugation, staining of cytospins with hematoxylin-eosin, and antibodies to human cytokeratins. Results: In 9 out of 16 cases (56%), neoplastic cells were detected in prefiltration samples, but none were found in postfiltration cytospins. Conclusion: IOBS combined with appropriate filtration could be a very useful and safe tool in reducing allogeneic blood transfusion in cancer patients.