Evaluation of Solvent/Detergent-Treated Plasma in Patients with a Prolonged Prothrombin Time


Joan C. Pehta, MD, c/o Kathleen Beach, MD, VI Technologies, Inc., 134 Coolidge Avenue, Watertown, MA 02472 (USA), Tel. +1 617 926 1551, Fax +1 617 923 2318, E-Mail Kathleen.Beach@Vltechnologies.com


AbstractObjectives: To compare the laboratory and clinical out-come of patients who received solvent/detergent-treated plasma (SDP) and fresh-frozen plasma (FFP). Methods: A randomized, double-blinded study to assess the ability of SDP and FFP to reduce a prolonged prothrombin time (PT to ≤ 15 s in patients with acquired coagulation deficits. Results: 45 patients (22 SDP vs. 23 FFP) were treated with 71 infusions. There were no significant differences in mean dose of plasma infused (7.8 ml/kg for SDP vs. 8.0 ml/kg for FFP, p = 0.46), percentage of patients who corrected their PT to ≤ 15 s (32% for SDP vs. 26% for FFP, p = 0.67), or percentage of patients whose bleeding ceased (27% for SDP vs. 22% for FFP). Conclusion: No clinical or statistically significant differences were observed after infusion with SDP or FFP in patients with acquired coagulation deficits.