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Cyclic expression of esr9 gene in Xenopus presomitic mesoderm

Authors

  • Y. Li,

    1. Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
      Tel: + 49 6221 42 4690
      Fax: + 49 6221 42 4692
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  • U. Fenger,

    1. Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
      Tel: + 49 6221 42 4690
      Fax: + 49 6221 42 4692
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  • C. Niehrs,

    1. Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
      Tel: + 49 6221 42 4690
      Fax: + 49 6221 42 4692
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  • and 1 () N. Pollet

    Corresponding author
    1. Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
      Tel: + 49 6221 42 4690
      Fax: + 49 6221 42 4692
    Search for more papers by this author

✉ e-mail: Nicolas.Pollet@ibaic.u-psud.fr

Abstract

Abstract During somitogenesis, the cycling expression of members of the Notch signalling cascade is involved in a segmentation clock that regulates the periodic budding of somites in chicken, mouse, and zebrafish. In frog, genes with cycling expression in the presomitic mesoderm have not been reported. Here, we describe the expression of Xenopus esr9 and esr10, two new members of the Hairy/Enhancer of split related family of bHLH proteins. We show that they are expressed in a highly dynamic fashion, with their mRNA levels oscillating periodically in the presomitic mesoderm during somitogenesis. This dynamic expression is independent of de novo protein synthesis. Thus, expression of esr9 and esr10 is an indicator of the segmentation clock in the amphibian embryo. This confirms the evolutionary conservation of a molecular pathway involved in vertebrate segmentation clock.

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