• 1
    Jörnvall, H. (1994) The alcohol dehydrogenase system. EXS 71, 221229.
  • 2
    Duester, G., Farres, J., Felder, M.R., Holmes, R.S., Höög, J.O., Pares, X., Plapp, B.V., Yin, S.J. & Jörnvall, H. (1999) Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family. Biochem. Pharmacol. 58, 389395.
  • 3
    Danielsson, O. & Jörnvall, H. (1992) ‘Enzymogenesis’: classical liver alcohol dehydrogenase origin from the glutathione-dependent formaldehyde dehydrogenase line. Proc. Natl Acad. Sci. USA 89, 92479251.
  • 4
    Nordling, E., Persson, B. & Jörnvall, H. (2002) Differential multiplicity of MDR alcohol dehydrogenases: enzyme genes in the human genome versus those in organisms initially studied. Cell Mol. Life Sci. 59, 10701075.
  • 5
    Giri, P.R., Linnoila, M., O'Neill, J.B. & Goldman, D. (1989) Distribution and possible metabolic role of class III alcohol dehydrogenase in the human brain. Brain Res. 481, 131141.
  • 6
    Beisswenger, T.B., Holmquist, B. & Vallee, B.L. (1985) chi-ADH is the sole alcohol dehydrogenase isozyme of mammalian brains: implications and inferences. Proc. Natl Acad. Sci. USA 82, 83698373.
  • 7
    Haselbeck, R.J. & Duester, G. (1998) ADH4-lacZ. transgenic mouse reveals alcohol dehydrogenase localization in embryonic midbrain/hindbrain, otic vesicles, and mesencephalic, trigeminal, facial, and olfactory neural crest. Alcohol Clin. Exp. Res. 22, 16071613.
  • 8
    Saleem, M.M., al Tamer, Y.Y., Skursky, L. & Al Habbal, Z. (1984) Alcohol dehydrogenase activity in the human tissues. Biochem. Med. 31, 19.
  • 9
    Jelski, W., Chrostek, L., Szmitkowski, M. & Laszewicz, W. (2002) Activity of class I, II, III, and IV alcohol dehydrogenase isoenzymes in human gastric mucosa. Dig. Dis. Sci. 47, 15541557.
  • 10
    Matsumoto, M., Yokoyama, H., Shiraishi, H., Suzuki, H., Kato, S., Miura, S. & Ishii, H. (2001) Alcohol dehydrogenase activities in the human gastric mucosa: Effects of Helicobacter pylori infection, sex, age, and the part of the stomach. Alcoholism-Clin. Exp Res. 25, 29S34S.
  • 11
    Martinez, S.E., Vaglenova, J., Sabria, J., Martinez, M.C., Farres, J. & Pares, X. (2001) Distribution of alcohol dehydrogenase mRNA in the rat central nervous system. Consequences for brain ethanol and retinoid metabolism. Eur. J. Biochem. 268, 50455056.
    Direct Link:
  • 12
    Deltour, L., Foglio, M.H. & Duester, G. (1999) Impaired retinol utilization in Adh4 alcohol dehydrogenase mutant mice. Dev. Genet. 25, 110.
  • 13
    Dagerlind, A., Friberg, K., Bean, A.J. & Hökfelt, T. (1992) Sensitive mRNA detection using unfixed tissue: combined radioactive and non-radioactive in situ hybridization histochemistry. Histochemistry 98, 3949.
  • 14
    Uotila, L. & Koivusalo, M. (1974) Formaldehyde dehydrogenase from human liver. Purification, properties, and evidence for the formation of glutathione thiol esters by the enzyme. J. Biol. Chem. 249, 76537663.
  • 15
    von Wartburg, J.P., Bethune, J.L. & Vallee, B.L. (1964) Human liver-alcohol dehydrogenase. Kinetic and physicochemical properties. Biochemistry 3, 17751782.
  • 16
    Ang, H.L., Deltour, L., Zgombic-Knight, M., Wagner, M.A. & Duester, G. (1996) Expression patterns of class I and class IV alcohol dehydrogenase genes in developing epithelia suggest a role for alcohol dehydrogenase in local retinoic acid synthesis. Alcohol Clin. Exp. Res. 20, 10501064.
  • 17
    Estonius, M., Danielsson, O., Höög, J.O., Persson, H. & Jörnvall, H. (1993) Tissue distribution of alcohol and sorbitol dehydrogenase mRNAs. Adv. Exp. Med. Biol. 328, 545553.
  • 18
    Estonius, M., Svensson, S. & Höög, J.O. (1996) Alcohol dehydrogenase in human tissues: localisation of transcripts coding for five classes of the enzyme. FEBS Lett. 397, 338342.
  • 19
    Szalai, G., Duester, G., Friedman, R., Jia, H., Lin, S., Roe, B.A. & Felder, M.R. (2002) Organization of six functional mouse alcohol dehydrogenase genes on two overlapping bacterial artificial chromosomes. Eur. J. Biochem. 269, 224232.
  • 20
    Casanova-Schmitz, M., David, R.M. & Heck, H.D. (1984) Oxidation of formaldehyde and acetaldehyde by NAD+-dependent dehydrogenases in rat nasal mucosal homogenates. Biochem. Pharmacol. 33, 11371142.
  • 21
    Keller, D.A., Heck, H.D., Randall, H.W. & Morgan, K.T. (1990) Histochemical localization of formaldehyde dehydrogenase in the rat. Toxicol. Appl. Pharmacol. 106, 311326.
  • 22
    Haselbeck, R.J. & Duester, G. (1997) Regional restriction of alcohol/retinol dehydrogenases along the mouse gastrointestinal epithelium. Alcohol Clin. Exp. Res. 21, 14841490.
  • 23
    Zgombic-Knight, M., Foglio, M.H. & Duester, G. (1995) Genomic structure and expression of the ADH7 gene encoding human class IV alcohol dehydrogenase, the form most efficient for retinol metabolism in vitro. J. Biol. Chem. 270, 43054311.
  • 24
    Engeland, K. & Maret, W. (1993) Extrahepatic, differential expression of four classes of human alcohol dehydrogenase. Biochem. Biophys. Res. Commun. 193, 4753.
  • 25
    Boleda, M.D., Saubi, N., Farres, J. & Pares, X. (1993) Physiological substrates for rat alcohol dehydrogenase classes: aldehydes of lipid peroxidation, omega-hydroxyfatty acids, and retinoids. Arch. Biochem. Biophys. 307, 8590.
  • 26
    Molotkov, A., Fan, X., Deltour, L., Foglio, M.H., Martras, S., Farres, J., Pares, X. & Duester, G. (2002) Stimulation of retinoic acid production and growth by ubiquitously expressed alcohol dehydrogenase Adh3. Proc. Natl Acad. Sci. USA 99, 53375342.
  • 27
    Person, R.E., Chen, H., Fantel, A.G. & Juchau, M.R. (2000) Enzymic catalysis of the accumulation of acetaldehyde from ethanol in human prenatal cephalic tissues: evaluation of the relative contributions of CYP2E1, alcohol dehydrogenase, and catalase/peroxidases. Alcohol Clin. Exp. Res. 24, 14331442.
  • 28
    Zimatkin, S.M., Liopo, A.V. & Deitrich, R.A. (1999) Oxidation of ethanol to acetaldehyde in brain and the possible behavioral consequences. Adv. Exp. Med. Biol. 463, 231236.
  • 29
    McBride, W.J., Li, T.K., Deitrich, R.A., Zimatkin, S., Smith, B.R. & Rodd-Henricks, Z.A. (2002) Involvement of acetaldehyde in alcohol addiction. Alcohol Clin. Exp. Res. 26, 114119.
  • 30
    Johansson, B. (1992) A review of the pharmacokinetics and pharmacodynamics of disulfiram and its metabolites. Acta Psychiatr. Scand. Suppl. 369, 1526.
  • 31
    McCaffery, P. & Dräger, U.C. (2000) Regulation of retinoic acid signaling in the embryonic nervous system: a master differentiation factor. Cytokine Growth Factor Rev. 11, 233249.
  • 32
    Zetterström, R.H., Lindqvist, E., Mata de Urquiza, A., Tomac, A., Eriksson, U., Perlmann, T. & Olson, L. (1999) Role of retinoids in the CNS: differential expression of retinoid binding proteins and receptors and evidence for presence of retinoic acid. Eur. J. Neurosci. 11, 407416.
  • 33
    Ang, H.L., Deltour, L., Hayamizu, T.F., Zgombic-Knight, M. & Duester, G. (1996) Retinoic acid synthesis in mouse embryos during gastrulation and craniofacial development linked to class IV alcohol dehydrogenase gene expression. J. Biol. Chem. 271, 95269534.
  • 34
    McCaffery, P. & Dräger, U.C. (1994) High levels of a retinoic acid-generating dehydrogenase in the meso-telencephalic dopamine system. Proc. Natl Acad. Sci. USA 91, 77727776.
  • 35
    Zetterström, R.H., Simon, A., Giacobini, M.M., Eriksson, U. & Olson, L. (1994) Localization of cellular retinoid-binding proteins suggests specific roles for retinoids in the adult central nervous system. Neuroscience 62, 899918.
  • 36
    Misner, D.L., Jacobs, S., Shimizu, Y., de Urquiza, A.M., Solomin, L., Perlmann, T., De Luca, L.M., Stevens, C.F. & Evans, R.M. (2001) Vitamin A deprivation results in reversible loss of hippocampal long-term synaptic plasticity. Proc. Natl Acad. Sci. USA 98, 1171411719.
  • 37
    Thompson, H.G., Maynard, T.M., Shatzmiller, R.A. & Lamantia, A.S. (2002) Retinoic acid signaling at sites of plasticity in the mature central nervous system. J. Comp Neurol. 452, 228241.
  • 38
    Takahashi, J., Palmer, T.D. & Gage, F.H. (1999) Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures. J. Neurobiol. 38, 6581.
  • 39
    Mori, O., Haseba, T., Kameyama, K., Shimizu, H., Kudoh, M., Ohaki, O., Arai, Y., Yamazaki, M. & Asano, G. (2000) Histological distribution of class III alcohol dehydrogenase in human brain. Brain Res. 852, 186190.
  • 40
    Kerr, J.T., Maxwell, D.S. & Crabb, D.W. (1989) Immunocytochemistry of alcohol dehydrogenase in the rat central nervous system. Alcohol Clin. Exp. Res. 13, 730736.
  • 41
    Rout, U.K. (1992) Alcohol dehydrogenases in the brain of mice. Alcohol Clin. Exp. Res. 16, 286289.
  • 42
    Duester, G. (2000) Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acid. Eur. J. Biochem. 267, 43154324.