SEARCH

SEARCH BY CITATION

References

  • 1
    Kopelman, P.G. (2000) Obesity as a medical problem. Nature 404, 635643.
  • 2
    Moltz, J.H. & McDonald, J.K. (1985) Neuropeptide Y: direct and indirect action on insulin secretion in the rat. Peptides 6, 11551159.
  • 3
    Inui, A. (1999) Neuropeptide Y feeding receptors: are multiple subtypes involved?. Trends Pharmacol. Sci. 20, 4346.DOI: 10.1016/s0165-6147(99)01303-6
  • 4
    Kalra, S.P. & Crowley, W.R. (1992) Neuropeptide Y: a novel neuroendocrine peptide in the control of pituitary hormone secretion, and its relation to luteinizing hormone. Front Neuroendocrinol. 13, 146.
  • 5
    McDonald, J.K., Lumpkin, M.D., Samson, W.K., McCann, S.M. (1985) Neuropeptide Y affects secretion of luteinizing hormone and growth hormone in ovariectomized rats. Proc. Natl Acad. Sci. USA 82, 561564.
  • 6
    Wahlestedt, C., Yanaihara, N., Hakanson, R. (1986) Evidence for different pre- and post-junctional receptors for neuropeptide Y and related peptides. Regul. Pept. 13, 307318.
  • 7
    Flood, J.F., Hernandez, E.N., Morley, J.E. (1987) Modulation of memory processing by neuropeptide Y. Brain Res. 421, 280290.
  • 8
    Jolicoeur, F.B., Michaud, J.N., Rivest, R., Menard, D., Gaudin, D., Fournier, A., St-Pierre, S. (1991) Neurobehavioral profile of neuropeptide Y. Brain Res. Bull. 26, 265268.
  • 9
    Jolicoeur, F.B., Michaud, J.N., Menard, D., Fournier, A. (1991) In vivo structure activity study supports the existence of heterogeneous neuropeptide Y receptors. Brain Res. Bull. 26, 309311.
  • 10
    Esteban, J., Chover, A.J., Sanchez, P.A., Mico, J.A., Gibert-Rahola, J. (1989) Central administration of neuropeptide Y induces hypothermia in mice. Possible interaction with central noradrenergic systems. Life Sci. 45, 23952400.
  • 11
    Clark, J.T., Kalra, P.S., Kalra, S.P. (1997) Neuropeptide Y stimulates feeding but inhibits sexual behavior in rats. Obes. Res. 5, 275283.
  • 12
    Calza, L., Giardino, L., Zanni, M., Velardo, A., Parchi, P., Marrama, P. (1990) Daily changes of neuropeptide Y-like immunoreactivity in the suprachiasmatic nucleus of the rat. Regul. Pept 27, 127137.
  • 13
    McAuley, M.A., Chen, X., Westfall, T.C. (1993) Central cardiovascular actions of neuropeptide Y. In The Biology of Neuropeptide Y and Related Peptides (Colmers, W.F. & Wahlestedt, C., eds), pp. 389418. Humana Press Inc., Totowa, NJ.
  • 14
    Heilig, M. (1993) Neuropepitde Y in relation to behavior and psychiatric disorders: some animal and clinical observations. In The Biology of Neuropeptide Y and Related Peptides (Colmers, W.F. & Wahlestedt, C., eds), pp. 511555. Humana Press Inc., Totowa, NJ.
  • 15
    Thiele, T.E., Marsh, D.J., Ste. Marie, L., Bernstein, I.L., Palmiter, R.D. (1998) Ethanol consumption and resistance are inversely related to neuropeptide Y levels. Nature 396, 366369.DOI: 10.1038/24614
  • 16
    Tatemoto, K., Carlquist, M., Mutt, V. (1982) Neuropeptide Y – a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature 296, 659660.
  • 17
    Krause, J., Eva, C., Seeburg, P.H., Sprengel, R. (1992) Neuropeptide Y1 subtype pharmacology of a recombinantly expressed neuropeptide receptor. Mol. Pharmacol. 41, 817821.
  • 18
    Larhammar, D., Blomqvist, A.G., Yee, F., Jazin, E., Yoo, H., Wahlested, C. (1992) Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type. J. Biol. Chem. 267, 1093510938.
  • 19
    Herzog, H., Hort, Y.J., Ball, H.J., Hayes, G., Shine, J., Selbie, L.A. (1992) Cloned human neuropeptide Y receptor couples to two different second messenger systems. Proc. Natl Acad. Sci. USA 89, 57945798.
  • 20
    Rose, P.M., Fernandes, P., Lynch, J.S., Frazier, S.T., Fisher, S.M., Kodukula, K., Kienzle, B., Seethala, R. (1995) Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor. J. Biol. Chem. 270, 29038.
  • 21
    Gerald, C., Walker, M.W., Vaysse, P.J., He, C., Branchek, T.A., Weinshank, R.L. (1995) Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype. J. Biol. Chem. 270, 2675826761.
  • 22
    Gehlert, D.R., Beavers, L.S., Johnson, D., Gackenheimer, S.L., Schober, D.A., Gadski, R.A. (1996) Expression cloning of a human brain neuropeptide Y Y2 receptor. Mol. Pharmacol. 49, 224228.
  • 23
    Gerald, C., Walker, M.W., Criscione, L., Gustafson, E.L., Batzl-Hartmann, C., Smith, K.E., Vaysse, P., Durkin, M.M., Laz, T.M., Linemeyer, D.L., Schaffhauser, A.O., Whitebread, S., Hofbauer, K.G., Taber, R.I., Branchek, T.A., Weinshank, R.L. (1996) A receptor subtype involved in neuropeptide-Y-induced food intake. Nature 382, 168171.
  • 24
    Weinberg, D.H., Sirinathsinghji, D.J., Tan, C.P., Shiao, L.L., Morin, N., Rigby, M.R., Heavens, R.H., Rapoport, D.R., Bayne, M.L., Cascieri, M.A., Strader, C.D., Linemeyer, D.L., MacNeil, D.J. (1996) Cloning and expression of a novel neuropeptide Y receptor. J. Biol. Chem. 271, 1643516438.
  • 25
    Lundell, I., Blomqvist, A.G., Berglund, M.M., Schober, D.A., Johnson, D., Statnick, M.A., Gadski, R.A., Gehlert, D.R., Larhammar, D. (1995) Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY. J. Biol. Chem 270, 2912329128.
  • 26
    Bard, J.A., Walker, M.W., Branchek, T.A., Weinshank, R.L. (1995) Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. J. Biol. Chem. 270, 2676226765.
  • 27
    Michel, M.C., Beck-Sickinger, A., Cox, H., Doods, H.N., Herzog, H., Larhammar, D., Quirion, R., Schwartz, T., Westfall, T. (1998) XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol. Rev. 50, 143150.
  • 28
    Beck-Sickinger, A.G. (1996) Structural characterization and binding sites of G-protein-coupled receptors. Drug Discovery Today 1, 502513.DOI: 10.1016/s1359-6446(96)10042-8
  • 29
    Criscione, L., Rigollier, P., Batzl-Hartmann, C., Rueger, H., Stricker-Krongrad, A., Wyss, P., Brunner, L., Whitebread, S., Yamaguchi, Y., Gerald, C., Heurich, R.O., Walker, M.W., Chiesi, M., Schilling, W., Hofbauer, K.G., Levens, N. (1998) Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y5 receptor. J. Clin. Invest 102, 21362145.
  • 30
    Wieland, H.A., Engel, W., Eberlein, W., Rudolf, K., Doods, H.N. (1998) Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents. Br. J. Pharmacol. 125, 549555.
  • 31
    Liao, S., Alfaro-Lopez, J., Shenderovich, M.D., Hosohata, K., Lin, J., Li, X., Stropova, D., Davis, P., Jernigan, K.A., Porreca, F., Yamamura, H.I., Hruby, V.J. (1998) De novo design, synthesis, and biological activities of high-affinity and selective non-peptide agonists of the delta-opioid receptor. J. Med. Chem. 41, 47674776.DOI: 10.1021/jm980374r
  • 32
    Wyss, P., Stricker-Krongrad, A., Brunner, L., Miller, J., Crossthwaite, A., Whitebread, S., Criscione, L. (1998) The pharmacology of neuropeptide Y (NPY) receptor-mediated feeding in rats characterizes better Y5 than Y1, but not Y2 or Y4 subtypes. Regul. Pept. 75–76, 363371.
  • 33
    Cabrele, C., Langer, M., Bader, R., Wieland, H.A., Doods, H.N., Zerbe, O., Beck-Sickinger, A.G. (2000) The first selective agonist at the neuropeptide Y Y5-receptor increases food intake in rats. J. Biol. Chem. 275, 3604336048.DOI: 10.1074/jbc.m000626200
  • 34
    Rudolf, K., Eberlein, W., Engel, W., Wieland, H.A., Willim, K.D., Entzeroth, M., Wienen, W., Beck-Sickinger, A.G., Doods, H.N. (1994) The first highly potent and selective non-peptide neuropeptide Y Y1 receptor antagonist: BIBP3226. Eur J. Pharmacol. 271, R11R13.
  • 35
    Hipskind, P.A., Lobb, K.L., Nixon, J.A., Britton, T.C., Bruns, R.F., Catlow, J., Dieckman-McGinty, D.K., Gackenheimer, S.L., Gitter, B.D., Iyengar, S., Schober, D.A., Simmons, R.M., Swanson, S., Zarrinmayeh, H., Zimmerman, D.M., Gehlert, D.R. (1997) Potent and selective 1,2,3-trisubstituted indole NPY Y-1 antagonists. J. Med. Chem. 40, 37123714.DOI: 10.1021/jm970512x
  • 36
    Daniels, A.J., Matthews, J.E., Slepetis, R.J., Jansen, M., Viveros, O.H., Tadepalli, A., Harrington, W., Heyer, D., Landavazo, A., Leban, J.J. et al. (1995) High-affinity neuropeptide Y receptor antagonists. Proc. Natl Acad. Sci. USA 92, 90679071.
  • 37
    Schober, D.A., Van Abbema, A.M., Smiley, D.L., Bruns, R.F., Gehlert, D.R. (1998) The neuropeptide Y Y1 antagonist, 1229U91, a potent agonist for the human pancreatic polypeptide-preferring (NPY Y4) receptor. Peptides 19, 537542.DOI: 10.1016/s0196-9781(97)00455-5
  • 38
    McCrea, K., Wisialowski, T., Cabrele, C., Church, B., Beck-Sickinger, A., Kraegen, E., Herzog, H. (2000) 2–36[K4,RYYSA (19–23)]PP a novel Y5-receptor preferring ligand with strong stimulatory effect on food intake. Regul. Pept. 87, 4758.DOI: 10.1016/s0167-0115(99)00108-1
  • 39
    Ingenhoven, N. & Beck-Sickinger, A.G. (1997) Fluorescent labelled analogues of neuropeptide Y for the characterization of cells expressing NPY receptor subtypes. J. Recept. Signal Transduct. Res. 17, 407418.
  • 40
    Lundell, I., Statnick, M.A., Johnson, D., Schober, D.A., Starback, P., Gehlert, D.R., Larhammar, D. (1996) The cloned rat pancreatic polypeptide receptor exhibits profound differences to the orthologous receptor. Proc. Natl Acad. Sci. USA 93, 51115115.
  • 41
    Eriksson, H., Berglund, M.M., Holmberg, S.K., Kahl, U., Gehlert, D.R., Larhammar, D. (1998) The cloned guinea pig pancreatic polypeptide receptor Y4 resembles more the human Y4 than does the rat Y4. Regul. Pept. 75–76, 2937.
  • 42
    Yang, J.T., Wu, C.S., Martinez, H.M. (1986) Calculation of protein conformation from circular dichroism. Methods Enzymol. 130, 208269.
  • 43
    Larhammar, D. (1996) Evolution of neuropeptide Y, peptide YY and pancreatic polypeptide. Regul. Pept. 62, 111.DOI: 10.1016/0167-0115(95)00169-7
  • 44
    Hoffmann, S., Rist, B., Videnov, G., Jung, G., Beck-Sickinger, A.G. (1996) Structure-affinity studies of C-terminally modified analogs of neuropeptide Y led to a novel class of peptidic Y1 receptor antagonist. Regul. Pept. 65, 6170.DOI: 10.1016/0167-0115(96)00073-0
  • 45
    Beck-Sickinger, A.G., Wieland, H.A., Wittneben, H., Willim, K.D., Rudolf, K., Jung, G. (1994) Complete l-alanine scan of neuropeptide Y reveals ligands binding to Y1 and Y2 receptors with distinguished conformations. Eur. J. Biochem. 225, 947958.
  • 46
    Cabrele, C. & Beck-Sickinger, A.G. (2000) Molecular characterization of the ligand–receptor interaction of the neuropeptide Y family. J. Pept. Sci. 6, 97122.
  • 47
    Kirby, D.A., Boublik, J.H., Rivier, J.E. (1993) Neuropeptide Y: Y1 and Y2 affinities of the complete series of analogues with single d-residue substitutions. J. Med. Chem 36, 38023808.
  • 48
    Rist, B., Wieland, H.A., Willim, K.D., Beck-Sickinger, A.G. (1995) A rational approach for the development of reduced-size analogues of neuropeptide Y with high affinity to the Y1 receptor. J. Pept. Sci. 1, 341348.
  • 49
    Kirby, D.A., Koerber, S.C., Craig, A.G., Feinstein, R.D., Delmas, L., Brown, M.R., Rivier, J.E. (1993) Defining structural requirements for neuropeptide Y receptors using truncated and conformationally restricted analogues. J. Med. Chem. 36, 385393.
  • 50
    Fuhlendorff, J., Gether, U., Aakerlund, L., Langeland-Johansen, N., Thogersen, H., Melberg, S.G., Olsen, U.B., Thastrup, O., Schwartz, T.W. (1990) [Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist. Proc. Natl Acad. Sci. USA 87, 182186.