SEARCH

SEARCH BY CITATION

References

  • 1
    Prives, C. & Hall, P.A. (1999) The p53 pathway. J. Pathol. 187, 112126.DOI: 10.1002/(sici)1096-9896(199901)187:1<112::aid-path250>3.3.co;2-v
  • 2
    Appella, E. & Anderson, C.W. (2000) Signaling to p53: breaking the posttranslational modification code. Pathol. Biol. (Paris) 48, 227245.
  • 3
    El-Deiry, W.S. (1998) Regulation of p53 downstream genes. Semin. Cancer Biol. 8, 345357.DOI: 10.1006/scbi.1998.0097
  • 4
    Zhao, R., Gish, K., Murphy, M., Yin, Y., Notterman, D., Hoffman, W.H., Tom, E., Mack, D.H., Levine, A.J. (2000) Analysis of p53-regulated gene expression patterns using oligonucleotide arrays. Genes Dev. 14, 981993.
  • 5
    Smith, M.L., Ford, J.M., Hollander, M.C., Bortnick, R.A., Amundson, S.A., Seo, Y.R., Deng, C.-X., Hanawalt, P.C., Fornace, A.J. Jr (2000) p53-mediated DNA repair responses to UV radiation: studies of mouse cells lacking p53, 21, and/or gadd45 genes. Mol. Cell. Biol. 20, 37053714.
  • 6
    Dasika, G.K., Lin, S.-C., Zhao, S., Sung, P., Tomkinson, A., Lee, E.Y.-H.P. (1999) DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis. Oncogene 18, 78837899.
  • 7
    Gatti, A., Li, H.-H., Traugh, J.A., Liu, X. (2000) Phosphorylation of human p53 on Thr-55. Biochemistry 39, 98379842.DOI: 10.1021/bi992454i
  • 8
    Waterman, M.J.F., Stavridi, E.S., Waterman, J.L.F., Halazonetis, T.D. (1998) ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins. Nat. Genet. 19, 175178.
  • 9
    Shieh, S.-Y., Ikeda, M., Taya, Y., Prives, C. (1997) DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 91, 325334.
  • 10
    Siliciano, J.D., Canman, C.E., Taya, Y., Sakaguchi, K., Appella, E., Kastan, M.B. (1997) DNA damage induces phosphorylation of the amino terminus of p53. Genes Dev. 11, 34713481.
  • 11
    Sakaguchi, K., Saito, S.-I., Higashimoto, Y., Roy, S., Anderson, C.W., Appella, E. (2000) Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding. J. Biol. Chem. 275, 92789283.
  • 12
    Higashimoto, Y., Saito, S., Tong, X.-H., Hong, A., Sakaguchi, K., Appella, E., Anderson, C.W. (2000) Human p53 is phosphorylated on serines 6 and 9 in response to DNA damage-inducing agents. J. Biol. Chem. 275, 2319923203.
  • 13
    Persons, D.L., Yazlovitskaya, E.M., Pelling, J.C. (2000) Effect of extracellular signal-regulated kinase on p53 accumulation in response to cisplatin. J. Biol. Chem. 275, 3577835785.DOI: 10.1074/jbc.m004267200
  • 14
    Ashcroft, M., Taya, Y., Vousden, K.H. (2000) Stress signals utilize multiple pathways to stabilize p53. Mol. Cell. Biol. 20, 32243233.
  • 15
    Yih, L.-H. & Lee, T.-C. (2000) Arsenite induces p53 accumulation through an ATM-dependent pathway in human fibroblasts. Cancer Res. 60, 63466352.
  • 16
    Ye, R., Bodero, A., Zhou, B.B., Khanna, K.K., Lavin, M.F., Lees-Miller, S.P. (2000) The plant isoflavenoid, genistein, activates p53 and Chk2 in an ATM-dependent manner. J. Biol. Chem. 276, 48284833.DOI: 10.1074/jbc.m004894200
  • 17
    Ferbeyre, G., de Stanchina, E., Querido, E., Baptiste, N., Prives, C., Lowe, S.W. (2000) PML is induced by oncogenic ras and promotes premature senescence. Genes Dev. 14, 20152027.
  • 18
    Webley, K., Bond, J.A., Jones, C.J., Blaydes, J.P., Craig, A., Hupp, T., Wynford-Thomas, D. (2000) Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage. Mol. Cell. Biol. 20, 28032808.
  • 19
    Craig, A.L., Burch, L., Vojtesek, B., Mikutowska, J., Thompson, A., Hupp, T.R. (1999) Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers. Biochem. J. 342, 133141.DOI: 10.1042/0264-6021:3420133
  • 20
    Ko, L.J., Shieh, S.-Y., Chen, X., Jayaraman, L., Tamai, K., Taya, Y., Prives, C., Pan, Z.-Q. (1997) p53 is phosphorylated by Cdk7-cyclin H in a p36MAT1-dependent manner. Mol. Cell. Biol. 17, 72207229.
  • 21
    Sakaguchi, K., Herrera, J.E., Saito, S., Miki, T., Bustin, M., Vassilev, A., Anderson, C.W., Appella, E. (1998) DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev. 12, 28312841.
  • 22
    Tibbetts, R.S., Brumbaugh, K.M., Williams, J.M., Sarkaria, J.N., Cliby, W.A., Shieh, S.-Y., Taya, Y., Prives, C., Abraham, R.T. (1999) A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev. 13, 152157.
  • 23
    Oda, K., Arakawa, H., Tanaka, T., Matsuda, K., Tanikawa, C., Mori, T., Nishimori, H., Tamai, K., Tokino, T., Nakamura, Y., Taya, Y. (2000) p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell 102, 849862.
  • 24
    Bushmann, T., Potapova, O., Ivanov, V.N., Fuchs, S.Y., Henderson, S., Fried, V.A., Minamoto, T., Alarcon-Vargas, D., Pincus, M.R., Gaarde, W.A., Holbrook, N.J., Shiloh, Y., Ronai, Z. (2001) Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress. Mol. Cell. Biol. 21, 27432754.
  • 25
    Blaydes, J.P., Luciani, M.G., Pospisilova, S., Ball, H.M.-L., Vojtesek, B., Hupp, T.R. (2000) Stoichiometric phosphorylation of human p53 at Ser315 stimulates p53-dependent transcription. J. Biol. Chem. 276, 46994708.DOI: 10.1074/jbc.m003485200
  • 26
    Lu, H., Taya, Y., Ikeda, M., Levine, A.J. (1998) Ultraviolet radiation, but not (radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389. Proc. Natl Acad. Sci. USA 95, 63996402.
  • 27
    Kapoor, M. & Lozano, G. (1998) Functional activation of p53 via phosphorylation following DNA damage by UV but not γ radiation. Proc. Natl Acad. Sci. USA 95, 28342837.
  • 28
    Ito, A., Lai, C.-H., Zhao, X., Saito, S., Hamilton, M.H., Appella, E., Yao, T.-P. (2001) p300/CBP mediated-p53 acetylation is commonly induced by p53 activating agents and inhibited by MDM2. EMBO J. 20, 13311340.DOI: 10.1093/emboj/20.6.1331
  • 29
    Gostissa, M., Hengstermann, A., Fogal, V., Sandy, P., Schwarz, S.E., Scheffner, M., Del Sal, G. (1999) Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1. EMBO J. 18, 64626471.DOI: 10.1093/emboj/18.22.6462
  • 30
    Rodriguez, M.S., Desterro, J.M.P., Lain, S., Midgley, C.A., Lane, D.P., Hay, R.T. (1999) SUMO-1 modification activates the transcriptional response of p53. EMBO J. 18, 64556461.DOI: 10.1093/emboj/18.22.6455
  • 31
    Banin, S., Moyal, L., Shieh, S.-Y., Taya, Y., Anderson, C.W., Chessa, L., Smorodinsky, N.I., Prives, C., Reiss, Y., Shiloh, Y., Ziv, Y. (1998) Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 281, 16741677.
  • 32
    Canman, C.E., Lim, D.-S., Cimprich, K.A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M.B., Siliciano, J.D. (1998) Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281, 16771679.
  • 33
    Araki, R., Fukumura, R., Fujimori, A., Taya, Y., Shiloh, Y., Kurimasa, A., Burma, S., Li, G.C., Chen, D.J., Sato, K., Hoki, Y., Tatsumi, K., Abe, M. (1999) Enhanced phosphorylation of p53 serine 18 following DNA damage in DNA-dependent protein kinase catalytic subunit-deficient cells. Cancer Res. 59, 35433546.
  • 34
    Jimenez, G.S., Bryntesson, F., Torres-Arzayus, M.I., Priestley, A., Beeche, M., Saito, S., Sakaguchi, K., Appella, E., Jeggo, P.A., Taccioli, G.E., Wahl, G.M., Hubank, M. (1999) DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage. Nature 400, 8183.DOI: 10.1038/21913
  • 35
    Dumaz, N., Milne, D.M., Meek, D.W. (1999) Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15. FEBS Lett. 463, 312316.DOI: 10.1016/s0014-5793(99)01647-6
  • 36
    Shieh, S.-Y., Ahn, J., Tamai, K., Taya, Y., Prives, C. (2000) The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev. 14, 289300.
  • 37
    Knippschild, U., Milne, D.M., Campbell, L.E., DeMaggio, A.J., Christenson, E., Hoekstra, M.F., Meek, D.W. (1997) p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs. Oncogene 15, 17271736.
  • 38
    Chehab, N.H., Malikzay, A., Appel, M., Halazonetis, T.D. (2000) Chk2/hCds1 functions as a DNA damage checkpoint in G1 by stabilizing p53. Genes Dev. 14, 278288.
  • 39
    Chehab, N.H., Malikzay, A., Stavridi, E.S., Halazonetis, T.D. (1999) Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage. Proc. Natl Acad. Sci. USA 96, 1377713782.
  • 40
    Hirao, A., Kong, Y.-Y., Matsuoka, S., Wakeham, A., Ruland, J., Yoshida, H., Liu, D., Elledge, S.J., Mak, T.W. (2000) DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science 287, 18241827.DOI: 10.1126/science.287.5459.1824
  • 41
    Bulavin, D.V., Saito, S.-I., Hollander, M.C., Sakaguchi, K., Anderson, C.W., Appella, E., Fornace, A.J. Jr (1999) Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J. 18, 68456854.
  • 42
    Li, L., Ljungman, M., Dixon, J.E. (2000) The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53. J. Biol. Chem. 275, 24102414.
  • 43
    Cuddihy, A.R., Wong, A.H.-T., Tam, N.W.N., Li, S., Koromilas, A.E. (1999) The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro. Oncogene 18, 26902702.
  • 44
    Keller, D.M., Zeng, X., Wang, Y., Zhang, M., Kapoor, M., Shu, H., Goodman, R., Lozano, G., Zhan, Y., Lu, H. (2001) A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. Mol. Cell 7, 283292.
  • 45
    Liu, L., Scolnick, D.M., Trievel, R.C., Zhang, H.B., Marmorstein, R., Halazonetis, T.D., Berger, S.L. (1999) p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage. Mol. Cell. Biol. 19, 12021209.
  • 46
    Avantaggiati, M.L., Ogryzko, V., Gardner, K., Giordano, A., Levine, A.S., Kelly, K. (1997) Recruitment of p300/CBP in p53-dependent signal pathways. Cell 89, 11751184.
  • 47
    Lill, N.L., Grossman, S.R., Ginsberg, D., DeCaprio, J., Livingston, D.M. (1997) Binding and modulation of p53 by p300/CBP coactivators. Nature 387, 823827.DOI: 10.1038/42981
  • 48
    Juan, L.-J., Shia, W.-J., Chen, M.-H., Yang, W.-M., Seto, E., Lin, Y.-S., Wu, C.-W. (2000) Histone deacetylases specifically down-regulate p53-dependent gene activation. J. Biol. Chem. 275, 2043620443.
  • 49
    Luo, J., Su, F., Chen, D., Shiloh, A., Gu, W. (2000) Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature 408, 377381.DOI: 10.1038/35042612
  • 50
    Unger, T., Sionov, R.V., Moallem, E., Yee, C.L., Howley, P.M., Oren, M., Haupt, Y. (1999) Mutations in serines 15 and 20 of human p53 impair its apoptotic activity. Oncogene 18, 32053212.
  • 51
    Chao, C., Saito, S., Anderson, C.W., Appella, E., Xu, Y. (2000) Phosphorylation of murine p53 at Ser-18 regulates the p53 responses to DNA damage. Proc. Natl Acad. Sci. USA 97, 1193611941.
  • 52
    Dumaz, N. & Meek, D.W. (1999) Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2. EMBO J. 18, 70027010.DOI: 10.1093/emboj/18.24.7002
  • 53
    Khosravi, R., Maya, R., Gottlieb, T., Oren, M., Shiloh, Y., Shkedy, D. (1999) Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage. Proc. Natl Acad. Sci. USA 96, 1497314977.
  • 54
    Hay, T.J. & Meek, D.W. (2000) Multiple sites of in vivo phosphorylation in the MDM2 oncoprotein cluster within two important functional domains. FEBS Lett. 478, 183186.DOI: 10.1016/s0014-5793(00)01850-0
  • 55
    Stad, R., Ramos, Y.F.M., Little, N., Grivell, S., Attema, J., van Der Eb, A.J., Jochemsen, A.G. (2000) Hdmx stabilizes Mdm2 and p53. J. Biol. Chem. 275, 2803928044.
  • 56
    Weber, J.D., Taylor, L.J., Roussel, M.F., Sherr, C.J., Bar-Sagi, D. (1999) Nucleolar Arf sequesters Mdm2 and activates p53. Nat. Cell. Biol. 1, 2026.DOI: 10.1038/8991
  • 57
    Bates, S., Phillips, A.C., Clark, P.A., Stott, F., Peters, G., Ludwig, R.L., Vousden, K.H. (1998) p14ARF links the tumour suppressors RB and p53. Nature 395, 124125.DOI: 10.1038/25867
  • 58
    Pearson, M., Carbone, R., Sebastiani, C., Cioce, M., Fagioli, M., Saito, S., Higashimoto, Y., Appella, E., Minucci, S., Pandolfi, P.P., Pelicci, P.G. (2000) PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature 406, 207210.DOI: 10.1038/35018127
  • 59
    Yu, A., Fan, H.-Y., Liao, D., Bailey, A.D., Weiner, A.M. (2000) Activation of p53 or loss of the Cockayne syndrome group B repair protein causes metaphase fragility of human U1, U2, and 5S genes. Mol. Cell. 5, 801810.
  • 60
    Kobet, E., Zeng, X., Zhu, Y., Keller, D., Lu, H. (2000) MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins. Proc. Natl Acad. Sci. USA 97, 1254712552.
  • 61
    Goodman, R.H. & Smolik, S. (2000) CBP/p300 in cell growth, transformation, and development. Genes Dev. 14, 15531577.
  • 62
    Scolnick, D.M., Chehab, N.H., Stavridi, E.S., Lien, M.C., Caruso, L., Moran, E., Berger, S.L., Halazonetis, T.D. (1997) CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein. Cancer Res. 57, 36933696.
  • 63
    Lambert, P.F., Kashanchi, F., Radonovich, M.F., Shiekhattar, R., Brady, J.N. (1998) Phosphorylation of p53 serine 15 increases interaction with CBP. J. Biol. Chem. 273, 3304833053.
  • 64
    Zhang, Y. & Xiong, Y. (1999) Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53. Mol. Cell. 3, 579591.
  • 65
    de Toledo, S.M., Azzam, E.I., Dahlberg, W.K., Gooding, T.B., Little, J.B. (2000) ATM complexes with HDM2 and promotes its rapid phosphorylation in a p53-independent manner in normal and tumor human cells exposed to ionizing radiation. Oncogene 19, 61856193.
  • 66
    Wang, S., Guo, M., Ouyang, H., Li, X., Cordon-Cardo, C., Kurimasa, A., Chen, D.J., Fuks, Z., Ling, C.C., Li, G.C. (2000) The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest. Proc. Natl Acad. Sci. USA 97, 15841588.
  • 67
    Jhappan, C., Yusufzai, T.M., Anderson, S., Anver, M.R., Merlino, G. (2000) The p53 response to DNA damage in vivo is independent of DNA-dependent protein kinase. Mol. Cell. Biol. 20, 40754083.
  • 68
    Ljungman, M., Zhang, F., Chen, F., Rainbow, A.J., McKay, B.C. (1999) Inhibition of RNA polymerase II as a trigger for the p53 response. Oncogene 18, 583592.
  • 69
    McKay, B.C., Ljungman, M., Rainbow, A.J. (1999) Potential roles for p53 in nucleotide excision repair. Carcinogenesis 20, 13891396.DOI: 10.1093/carcin/20.8.1389
  • 70
    Hwang, B.J., Ford, J.M., Hanawalt, P.C., Chu, G. (1999) Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair. Proc. Natl Acad. Sci. USA 96, 424428.
  • 71
    Tang, J.Y., Hwang, B.J., Ford, J.M., Hanawalt, P.C., Chu, G. (2000) Xeroderma pigmentosum p48 gene enhances global genomic repair and suppresses UV-induced mutagenesis. Mol. Cell. 5, 737744.
  • 72
    McKay, B.C. & Ljungman, M. (1999) Role for p53 in the recovery of transcription and protection against apoptosis induced by ultraviolet light. Neoplasia 1, 276284.
  • 73
    Alarcón, R., Koumenis, C., Geyer, R.K., Maki, C.G., Giaccia, A.J. (1999) Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation. Cancer Res. 59, 60466051.
  • 74
    Denko, N.C., Green, S.L., Edwards, D., Giaccia, A.J. (2000) p53 checkpoint-defective cells are sensitive to X rays, but not hypoxia. Exp. Cell Res. 258, 8291.DOI: 10.1006/excr.2000.4928
  • 75
    Seidita, G., Polizzi, D., Costanzo, G., Costa, S., Di Leonardo, A. (2000) Differential gene expression in p53-mediated G1 arrest of human fibroblasts after γ-irradiation or N-phosphoacetyl-l-aspartate treatment. Carcinogenesis 21, 22032210.DOI: 10.1093/carcin/21.12.2203
  • 76
    Jabbur, J.R., Huang, P., Zhang, W. (2000) DNA damage-induced phosphorylation of p53 at serine 20 correlates with p21 and Mdm-2 induction in vivo. Oncogene 19, 62036208.
  • 77
    Shikama, N., Lee, C.-W., France, S., Delavaine, L., Lyon, J., Krstic-Demonacos, M., La Thangue, N.B. (1999) A novel cofactor for p300 that regulates the p53 response. Mol. Cell. 4, 365376.
  • 78
    Vassilev, A., Yamauchi, J., Kotani, T., Prives, C., Avantaggiati, M.L., Qin, J., Nakatani, Y. (1998) The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily. Mol. Cell. 2, 869875.
  • 79
    Guo, A., Salomoni, P., Luo, J., Shih, A., Zhong, S., Gu, W., Paolo Pandolfi, P. (2000) The function of PML in p53-dependent apoptosis. Nat. Cell. Biol. 2, 730736.DOI: 10.1038/35036365
  • 80
    Fogal, V., Gostissa, M., Sandy, P., Zacchi, P., Sternsdorf, T., Jensen, K., Pandolfi, P.P., Will, H., Schneider, C., Del Sal, G. (2000) Regulation of p53 activity in nuclear bodies by a specific PML isoform. EMBO J. 19, 61856195.DOI: 10.1093/emboj/19.22.6185