Cardiovascular effects of desflurane following acute hemorrhage in dogs

Authors

  • Paulo S.P. Santos DVM, MS,

    1. From the Department of Veterinary Clinics and Surgery, Veterinary Surgery Graduate Program, Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal, Universidade Estadual Paulista. Jaboticabal, SP, Brazil (Santos, Andrade, Nunes), Faculdade de Agronomia e Medicina Veterinária, Universidade de Brasília, Brasília, Distrito Federal (Selmi), Universidade de Marília, Marília, SP, Brazil (Costa), and Faculdade de Medicina Veterinária, Universidade Federal de Minas Gerais. Belo Horizonte, MG (Faleiros).
    Search for more papers by this author
  • James N.B.M. Andrade DVM, MS,

    1. From the Department of Veterinary Clinics and Surgery, Veterinary Surgery Graduate Program, Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal, Universidade Estadual Paulista. Jaboticabal, SP, Brazil (Santos, Andrade, Nunes), Faculdade de Agronomia e Medicina Veterinária, Universidade de Brasília, Brasília, Distrito Federal (Selmi), Universidade de Marília, Marília, SP, Brazil (Costa), and Faculdade de Medicina Veterinária, Universidade Federal de Minas Gerais. Belo Horizonte, MG (Faleiros).
    Search for more papers by this author
  • André L. Selmi DVM, MS,

    1. From the Department of Veterinary Clinics and Surgery, Veterinary Surgery Graduate Program, Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal, Universidade Estadual Paulista. Jaboticabal, SP, Brazil (Santos, Andrade, Nunes), Faculdade de Agronomia e Medicina Veterinária, Universidade de Brasília, Brasília, Distrito Federal (Selmi), Universidade de Marília, Marília, SP, Brazil (Costa), and Faculdade de Medicina Veterinária, Universidade Federal de Minas Gerais. Belo Horizonte, MG (Faleiros).
    Search for more papers by this author
  • Jorge L.O. Costa DVM, MS,

    1. From the Department of Veterinary Clinics and Surgery, Veterinary Surgery Graduate Program, Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal, Universidade Estadual Paulista. Jaboticabal, SP, Brazil (Santos, Andrade, Nunes), Faculdade de Agronomia e Medicina Veterinária, Universidade de Brasília, Brasília, Distrito Federal (Selmi), Universidade de Marília, Marília, SP, Brazil (Costa), and Faculdade de Medicina Veterinária, Universidade Federal de Minas Gerais. Belo Horizonte, MG (Faleiros).
    Search for more papers by this author
  • Rafael R. Faleiros DVM, MS,

    1. From the Department of Veterinary Clinics and Surgery, Veterinary Surgery Graduate Program, Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal, Universidade Estadual Paulista. Jaboticabal, SP, Brazil (Santos, Andrade, Nunes), Faculdade de Agronomia e Medicina Veterinária, Universidade de Brasília, Brasília, Distrito Federal (Selmi), Universidade de Marília, Marília, SP, Brazil (Costa), and Faculdade de Medicina Veterinária, Universidade Federal de Minas Gerais. Belo Horizonte, MG (Faleiros).
    Search for more papers by this author
  • Newton Nunes DVM, MS, PhD

    1. From the Department of Veterinary Clinics and Surgery, Veterinary Surgery Graduate Program, Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal, Universidade Estadual Paulista. Jaboticabal, SP, Brazil (Santos, Andrade, Nunes), Faculdade de Agronomia e Medicina Veterinária, Universidade de Brasília, Brasília, Distrito Federal (Selmi), Universidade de Marília, Marília, SP, Brazil (Costa), and Faculdade de Medicina Veterinária, Universidade Federal de Minas Gerais. Belo Horizonte, MG (Faleiros).
    Search for more papers by this author

Professor Newton Nunes, DVM, MS, PhD, Departamento de Clínica e Cirurgia Veterinária, Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal, Universidade Estadual Paulista, Rod. Professor Paulo Donato Castelane, s.no. CEP 14870-000, Jaboticabal, SP, Brazil. E-mail: newton@fcav.unesp.br

Abstract

Objective: To determine the cardiovascular effects of desflurane in dogs following acute hemorrhage.

Design: Experimental study.

Animals: Eight mix breed dogs.

Interventions: Hemorrhage was induced by withdrawal of blood until mean arterial pressure (MAP) dropped to 60 mmHg in conscious dogs. Blood pressure was maintained at 60 mmHg for 1 hour by further removal or replacement of blood. Desflurane was delivered by facemask until endotracheal intubation could be performed and a desflurane expiratory end-tidal concentration of 10.5 V% was maintained.

Measurements and main results: Systolic, diastolic, and mean arterial blood pressure (SAP, DAP and MAP), central venous pressure (CVP), cardiac output (CO), stroke volume (SV), cardiac index (CI), systemic vascular resistance (SVR), heart rate (HR), respiratory rate (RR), partial pressure of carbon dioxide in arterial blood (PaCO2), and arterial pH were recorded before and 60 minutes after hemorrhage, and 5, 15, 30, 45 and 60 minutes after intubation. Sixty minutes after hemorrhage, SAP, DAP, MAP, CVP, CO, CI, SV, PaCO2, and arterial pH decreased, and HR and RR increased when compared with baselines values. Immediately after intubation, MAP and arterial pH decreased, and PaCO2 increased. Fifteen minutes after intubation SAP, DAP, MAP, arterial pH, and SVR decreased. At 30 and 45 minutes, MAP and DAP remained decreased and PaCO2 increased, compared with values measured after hemorrhage. Arterial pH increased after 30 minutes of desflurane administration compared with values measured 5 minutes after intubation.

Conclusions: Desflurane induced significant changes in blood pressure and arterial pH when administered to dogs following acute hemorrhage.

Ancillary