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Immunohistochemical Characteristics of Canine Aortic and Carotid Body Tumours


Comparative Pathology Laboratory, Department of Clinical Veterinary Science, University of Bristol Veterinary School, Langford, Bristol, UK


In an immunohistochemical study of 25 canine chemodectomas, 17 tumours were stained with antisera to neurone specific enolase and the same number were stained for synaptophysin; a single tumour was stained for S100. Staining for Ki-67 occurred in 18 cases; the Ki-67-labelling index and the intensity of immunostaining was increased in more pleomorphic and malignant tumours, as assessed on histological grounds. Immunohistochemistry did not aid in recognition of less well-differentiated tumours.