Megavitamin and dietary treatment in schizophrenia: a randomised, controlled trial
Article first published online: 20 APR 2002
Australian and New Zealand Journal of Psychiatry
Volume 33, Issue 1, pages 84–88, February 1999
How to Cite
Vaughan, K. and McConaghy, N. (1999), Megavitamin and dietary treatment in schizophrenia: a randomised, controlled trial. Australian and New Zealand Journal of Psychiatry, 33: 84–88. doi: 10.1046/j.1440-1614.1999.00527.x
- Issue published online: 20 APR 2002
- Article first published online: 20 APR 2002
- treatment trial
Objective: The aim of this study was to assess the efficacy of adjunctive megavitamin and dietary treatment in schizophrenia.
Method: A random allocation double-blind, controlled comparison of dietary supplement and megavitamin treatment, and an alternative procedure was given for 5 months to 19 outpatients with a diagnosis of schizophrenia. In addition to usual follow-up, the experimental group received amounts of megavitamins based on their individual serum vitamin levels plus dietary restriction based on Radioallergosorbent (RAST) tests. The control group received 25 mg vitamin C and were prescribed substances considered allergenic from the RAST test.
Results: Five months of treatment showed marked differences in serum levels of vitamins but no consistent self-reported symptomatic or behavioural differences between groups.
Conclusions: This study does not provide evidence supporting a positive relationship between regulation of levels of serum vitamins and clinical outcome in schizophrenia over 5 months.