1440-1681/asset/cep_bg_left.gif?v=1&s=94610148f173fa72ed6722456a9495d0f5469a5e)
1440-1681/asset/cep_centre.gif?v=1&s=d15dbde7e4b05a09ab4a0fa14e80b8d68a1ffb99)
Existence Of α1A- and α1B-Adrenoceptor Subtypes In Canine Mandibular Alveolar Arteries
Article first published online: 20 DEC 2001
DOI: 10.1046/j.1440-1681.2001.03507.x
Issue
1440-1681/asset/cover.gif?v=1&s=a348d8c520883138abe7615783701b4f4deccbe9 "Clinical and Experimental Pharmacology and Physiology")
Clinical and Experimental Pharmacology and Physiology
Volume 28, Issue 9, pages 716–720, September 2001
Additional Information
How to Cite
Taguchi, Y., Yang, X.-P. and Chiba, S. (2001), Existence Of α1A- and α1B-Adrenoceptor Subtypes In Canine Mandibular Alveolar Arteries. Clinical and Experimental Pharmacology and Physiology, 28: 716–720. doi: 10.1046/j.1440-1681.2001.03507.x
Publication History
- Issue published online: 20 DEC 2001
- Article first published online: 20 DEC 2001
- Abstract
- Article
- References
- Cited By
Keywords:
- α-adrenoceptor subtype;
- BMY 7378;
- cannula-inserting method;
- chloroethylclonidine;
- mandibular alveolar artery;
- WB4101
SUMMARY
1. The present study attempted to pharmacologically characterize the α-adrenoceptor subtypes mediating vasoconstriction in canine isolated and perfused mandibular alveolar artery (MAA).
2. Noradrenaline (NA) and phenylephrine (PE) induced a strong vasoconstriction in a dose-dependent manner. The PE-induced vascular constriction was significantly inhibited by treatment with prazosin. Xylazine evoked a moderate vascular constriction and the xylazine-induced response was suppressed by rauwolscine. The NA-induced response was partially inhibited by rauwolscine and the remaining response to NA was abolished by subsequent administration of prazosin.
3. Treatment of MAA with WB4101 produced a dose- dependent inhibition of NA-induced vasoconstriction. Pretreatment of tissues with 10 μmol/L chloroethylclonidine produced a slight and statistically significant inhibition of NA-induced responses. BMY 7378, a selective α1D-adrenoceptor antagonist, failed to significantly affect vasoconstrictor responses to NA.
4. The present results suggests that: (i) both α1- and α2-adrenoceptors are involved in vasoconstrictor responses in the canine MAA; and (ii) the α1-adrenoceptors involved in the vasoconstrictor responses in the MAA are characterized as mainly of the α1A- and partially of the α1B-adrenoceptor subtype.