Based on a paper presented at a meeting of the 11th International Congress of Endocrinology, Satellite Meeting on Endocrinology and Development, South Australia, November 2000. This paper has been peer reviewed.
A Hypothesis About A Mechanism For The Programming Of Blood Pressure And Vascular Disease In Early Life
Article first published online: 12 JAN 2002
Clinical and Experimental Pharmacology and Physiology
Volume 28, Issue 11, pages 948–951, November 2001
How to Cite
Martyn, C. and Greenwald, S. (2001), A Hypothesis About A Mechanism For The Programming Of Blood Pressure And Vascular Disease In Early Life. Clinical and Experimental Pharmacology and Physiology, 28: 948–951. doi: 10.1046/j.1440-1681.2001.03555.x
- Issue published online: 12 JAN 2002
- Article first published online: 12 JAN 2002
- blood pressure;
- fetal growth;
- vascular structure
1. There is now a great deal of evidence that people whose weight at birth was low tend to have higher blood pressure and increased risk of death from cardiovascular disease as adults.
2. We argue that, in fetuses whose growth is impaired, synthesis of elastin in the walls of the aorta and large arteries is deficient and that this deficiency leads to permanent changes in the mechanical properties of these vessels.
3. Over a lifetime, such changes could predispose an individual to higher blood pressure and cardiovascular disease.