Transferrin is necessary and sufficient for the neural effect on growth in amphibian limb regeneration blastemas
Article first published online: 27 OCT 2003
Development, Growth & Differentiation
Volume 39, Issue 6, pages 677–684, December 1997
How to Cite
Mescher, A. L., Connell, E., Hsu, C., Patel, C. and Overton, B. (1997), Transferrin is necessary and sufficient for the neural effect on growth in amphibian limb regeneration blastemas. Development, Growth & Differentiation, 39: 677–684. doi: 10.1046/j.1440-169X.1997.t01-5-00003.x
- Issue published online: 27 OCT 2003
- Article first published online: 27 OCT 2003
- Received 16 May 1997; revised 20 June 1997; accepted 20 June 1997.
- 1986. Evolution in vitro de cellules de blastemes de regeneration de membre d'Axolotl: Influence de l'insuline et d'extraits nerveux sur la proliferation cellulaire. Biol. Cell 58, 251–262 (in French with English abstract). , &
- 1988. Effect of transferrin on amphibian limb regeneration: A blastema cell culture study. Roux's Arch. Dev. Biol. 197, 193–196. , &
- 1980. Methods for growth of cultured cells in serum-free medium. Anal. Biochem. 102, 255–270. , &
- 1988. Blastema cell proliferation in vitro: Effects of limb amputation on the mitogenic activity of spinal cord extracts. Biol.Cell 62, 183–187. , &
- 1990. In vitro control of blastema cell proliferation by extracts from epidermal cap and mesenchyme of regenerating limbs of axolotls. Roux's Arch. Dev. Biol. 198, 443–447. , &
- 1988. Production in vitro by spinal cord of growth factor(s) acting on newt limb regeneration: Influence of regeneration of the nerve fibers. Dev. Brain Res. 38, 155–160. , &
- 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-binding dye. Anal. Biochem. 72, 248–254.
- 1989. The biology of iron. In Iron in Immunity, Cancer and Inflammation (Eds M.DeSousa & ), pp. 35–53. John Wiley & Sons, Chichester .
- 1986. Serum-free media. In Mammalian Cell Technology (Ed. W. G.Thilly), pp. 91–108. Butterworths, Boston .
- 1979. Stimulation of mitosis in cultured limb blastemata of the newt. Notophthalmus viridescens. J. Exp. Zool. 210, 245–252. , &
- 1985. Trophic factors from nerves. In Regulation of Vertebrate Limb Regeneration (Ed. R. E.Sicard), pp. 93–105. Oxford University Press, New York . , &
- 1978. Nerve trophic effects: An in vitro assay for factors involved in regulation of protein synthesis in regenerating amphibian limbs. J. Exp. Zool. 206, 347–354. , , &
- 1981. Nerve trophic effects: Partial purification from chick embryo brains of proteins that stimulate protein synthesis in cultured newt blastemata. Exp. Neurol. 73, 558–570. , , &
- 1978. Neurotrophic contribution to a proposed tripartite control of the mitotic cycle in the regeneration blastema of the newt. Notophthalmus (Triturus) viridescens. Am. Zool. 18, 855–868.
- 1985. In vitro studies of controlling factors in newt limb regeneration. In Regulation of Vertebrate Limb Regeneration (Ed. R. E.Sicard), pp. 106–127. Oxford University Press, New York . , &
- 1973. Forelimb regeneration from different levels of amputation in the newt, Notophthalmus viridescens: Length, rate and stages. Wilhelm Roux's Arch. Dev. Biol. 173, 263–282. , &
- 1977. Neurotrophic stimulation of DNA synthesis in the regenerating forelimb of the newt, Triturus. J. Exp. Zool. 199, 251–256. , &
- 1987. The transferrin gene. In Oncogenes, Genes, and Growth Factors (Ed. G.Guroff). pp. 277–309. John Wiley & Sons, New York . , , , &
- 1991. Axonal transport and release of transferrin in nerves of regenerating amphibian limbs. Dev. Biol. 147, 392–402. , , &
- 1984. A lipophilic iron chelator can replace transferrin as a stimulator of cell proliferation and differentiation. J. Cell Biol. 98, 596–601. , , &
- 1988. Evidence that transferrin supports cell proliferation by supplying iron for DNA synthesis. Exp. Cell Res. 176, 87–95. , , , &
- 1978. Neurotrophic control of the cell cycle during amphibian limb regeneration. J. Embryol. Exp. Morphol. 48, 169–175.
- 1984. A nerve-conditioning lesion accelerates limb regeneration in the newt. J. Exp. Zool. 232, 181–186. , , &
- 1982. Sciatin is a transferrin-like polypeptide J. Neurochem. 39, 315–320. , , , , &
- 1996. The cellular basis of limb regeneration in urodeles. Int. J. Dev. Biol. 40, 785–795.
- 1992. Axonal release of transferrin in peripheral nerves of axolotls during regeneration. In Keys for Regeneration, Monogr. Dev. Biol., Vol. 23 (Eds C. H.Taban, & ), pp. 100–109. Karger, Basel . , &
- 1981. Newt forelimb regeneration blastemas in vitro: Cellular response to explantation and effects of various growth-promoting substances. J. Exp. Zool. 216, 235–245. , & .
- 1984. ‘Trophic’ effects of transferrin on amphibian limb regeneration blastemas. J. Exp. Zool. 230, 485–490. , &
- 1986. Changes in the extracellular matrix and glycosaminoglycan synthesis during the initiation of regeneration in adult newt forelimbs. Anat. Rec. 214, 424–431. , &
- 1988. Transferrin and the growth-promoting effect of nerves. Int. Rev. Cytol. 110, 1–26. , &
- 1975. Denervation effects on DNA replication and mitosis during the initiation of limb regeneration in adult newts. Dev. Biol. 44, 187–197. , &
- 1990. The nucleotide sequence of Xenopus laevis transferrin mRNA. Nucleic Acid Res. 18, 6135. , , &
- 1986. Transferrin and the trophic effect of neural tissue on amphibian limb regeneration blastemas. Dev. Biol. 116, 138 –142. , &
- 1989. Growth control in limb regeneration. In Developmental Biology of the Axolotl (Eds J. B.Armstrong, & ), pp. 143–156. Oxford University Press, New York . , , &
- 1986. Cell cycle changes after denervation of the newt limb regenerate, studies in vitro. Experientia 42, 189–190. , , &
- 1985. Influence of denervation on the regeneration of pleurodele limbs. Cytophotometric study of nuclear DNA from blastemal cells. Differentiation 29, 116–120. , , , &
- 1966. The blood vessels of the regenerating limb of the adult newt, Triturus. J. Morphol. 118, 79–90. , &
- 1979. Neural regulation of cholinesterase in newt skeletal muscle: III. Regulation in vitro by proteins from chick embryo brains. J. Exp. Zool. 210, 463–472. , , &
- 1989. Molecular Cloning: A Laboratory Manual, 2nd edn. Cold Spring Harbor Laboratory Press, New York . , , &
- 1952. The influence of the nerve in regeneration of the amphibian extremity. Q. Rev. Biol. 27, 169–200.
- 1978. On the nature of the neurotrophic phenomenon in urodele limb regeneration. Am. Zool. 18, 829–841.
- 1989. Multiple interactions in juxtaposed monolayers of amphibian neuronal, epidermal, and mesodermal limb blastema cells. In Vitro Cell. Dev. Biol. 25, 849–856. , &
- 1975. Nerves and angiogenesis in amphibian limb regeneration. Nature 257, 224–225. , &
- 1979. Stages of forelimb regeneration in Ambystoma maculatum. J. Exp. Zool. 209, 395–416.
- 1995. Wound Repair, Regeneration and Artificial Tissues. R. G. Landes, Austin .
- 1995. Expression of the axolotl homologue of mouse chaperonin t-complex protein-1 during early development. Biochem. Biophys. Acta 1260, 157–166. , , , &
- 1989. Iron and Tumor Cell Growth. In Iron in Immunity, Cancer and Inflammation (Eds M.DeSousa, & ), pp. 261–282. John Wiley & Sons, Chichester .
- 1974. DNA synthesis without mitosis in amputated denervated forelimbs of larval axolotls. J. Exp. Zool. 190. 111–116. , , &
- 1987. Cell cycle controls and the role of nerves and the regenerate epithelium in urodele forelimb regeneration, possible modifications of basic concepts. Biochem. Cell Biol. 65, 739–749. , , &
- 1978. Neural control of cell cycle events in regenerating salamander limbs. Am. Zool. 18, 843–854. , &
- 1985. The role of transferrin receptors and iron delivery in mouse embryonic morphogenesis. Differentiation 30, 152–158. , , , , &
- 1978. Neural and hormonal stimulation of DNA and protein synthesis in cultured regeneration blastemata in the newt, Notophthalmus viridescens. Dev. Biol. 65, 183–192. , , &
- 1994. Developmental regulation of a matrix metallo-proteinase during regeneration of axolotl appendages. Dev. Biol. 166, 696–703. , &
- 1989. Axolotl pronephric duct cell migration is sensitive to phosphatidylinositol-specific phospholipase C. Development 105, 1–7. , &