Interferon treatment is not associated with a worsening of psychiatric symptoms in patients with hepatitis C
Article first published online: 25 DEC 2001
Journal of Gastroenterology and Hepatology
Volume 15, Issue 3, pages 300–303, March 2000
How to Cite
Mulder, R. T., Ang, M., Chapman, B., Ross, A., Stevens, I. F. and Edgar, C. (2000), Interferon treatment is not associated with a worsening of psychiatric symptoms in patients with hepatitis C. Journal of Gastroenterology and Hepatology, 15: 300–303. doi: 10.1046/j.1440-1746.2000.02090.x
- Issue published online: 25 DEC 2001
- Article first published online: 25 DEC 2001
- hepatitis C;
Aim: To study prospectively the psychiatric side effects of interferon-α in patients with hepatitis C.
Methods: Sixty-three consecutive patients at a hepatitis clinic were recruited. All were assessed using a psychiatric interview (SCID) and monitored using a self-reporting psychiatric symptom questionnaire (SCL-90).
Results: Patients on interferon did not suffer a drop in mood or an increase in anxiety or irritability. The subgroup with past depression also did not suffer an increase in depressive symptoms. No patients attempted suicide.
Conclusions: The risk of serious psychiatric symptoms when being treated with interferon-α may not be high. Psychiatric illness or the possibility of psychiatric complications should not be used as a reason to refuse this treatment to patients with hepatitis C.
© 2000 Blackwell Science Asia Pty Ltd