• 1
    Kao JH, Chen DS. Overview of Hepatitis B and C viruses. In: GoedertJJ, ed. Infectious Causes of Cancer: Targets for Intervention. Humana Press Inc, 2000: 31330.
  • 2
    Chen DS. From hepatitis to hepatoma: lessons from type B viral hepatitis. Science 1993; 262: 36970.
  • 3
    Chisari FV, Ferrari C. Hepatitis B immunopathogenesis. Annu. Rev. Immunol. 1995; 13: 2960.
  • 4
    Liaw YF, Tai DI, Chu CM, Pao CC, Chen TJ. Acute exacerbation in chronic type B hepatitis: comparison between HBeAg and antibody-positive patients. Hepatology 1987; 7: 203.
  • 5
    Lok AS, Lai CL. Acute exacerbations in Chinese patients with chronic hepatitis B virus (HBV) infection. Incidence, predisposing factors and etiology. J. Hepatol. 1990; 10: 2934.
  • 6
    Perrillo RP. Acute flares in chronic hepatitis B: the natural and unnatural history of an immunologically mediated liver disease. Gastroenterology 2001; 120: 100922.
  • 7
    Okamoto H, Imai M, Kametani M, Nakamura T, Mayumi M. Genomic heterogeneity of hepatitis B virus in a 54 year old woman who contracted the infection through materno-fetal transmission. Japan. J. Exp. Med. 1987; 57: 2316.
  • 8
    Magnius LO, Norder H. 1995 Subtypes, genotypes and molecular epidemiology of the hepatitis B virus as reflected by sequence variability of the S-gene. Intervirology 1995; 38: 2434.
  • 9
    Stuyver L, De Gendt S, Van Geyt C et al. A new genotype of hepatitis B virus: complete genome and phylogenetic relatedness. J. Gen. Virol. 2000; 81: 6774.
  • 10
    Okamoto H, Tsuda F, Sakugawa H et al. Typing hepatitis B virus by homology in nucleotide sequence: comparison of surface antigen subtypes. J. Gen. Virol. 1988; 69: 257583.
  • 11
    Simmonds P, Alberti A, Bonino F et al. A proposed system for the nomenclature for genotypes of hepatitis C virus. Hepatology 1994; 19: 13214.
  • 12
    Wu JC, Choo KB, Chen CM, Chen TZ, Huo TI, Lee SD. Genotyping of hepatitis D virus by restriction-fragment length polymorphism and relation to outcome of hepatitis D. Lancet 1995; 346: 93941.
  • 13
    Kao JH, Chen PJ, Lai MY et al. Genotypes of hepatitis C virus in Taiwan and the progression of liver disease. J. Clin. Gastroenterol. 1995; 21: 2337.
  • 14
    Lauer GM, Walker BD. Hepatitis C virus infection. N. Engl. J. Med. 2001; 345: 4152.
  • 15
    Kao JH, Chen PJ, Lai MY, Chen DS. Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B. Gastroenterology 2000; 118: 5549.
  • 16
    Ding X, Mizokami M, Yao G et al. Hepatitis B virus genotype distribution among Chronic hepatitis B virus carriers in Shanghai, China. Intervirol. 2001; 44: 437.
  • 17
    Fujie H, Moriya J, Shintani Y et al. Hepatitis B virus genotypes and hepatocellular carcinoma in Japan. Gastroenterology 2001; 120: 15645.
  • 18
    Kao JH, Wu NH, Chen PJ, Lai MY, Chen DS. Hepatitis B genotypes and the response to interferon therapy. J. Hepatol. 2000; 33: 9981002.
  • 19
    Thakur V, Guptan RC, Kazim SN, Malhotra V, Sarin SK. Profile, spectrum and significance of HBV genotypes in chronic liver disease patients in the Indian subcontinent. J. Gastroenterol. Hepatol. 2002; 17: 16570.
  • 20
    Gunther S, Fischer L, Pult I, Sterneck M, Will H. Naturally occurring variants of hepatitis B virus. Adv. Virus Res. 1999; 52: 12537.
  • 21
    Hunt CM, McGill JM, Allen MI, Condreay LD. Clinical relevance of hepatitis B viral mutations. Hepatology 2000; 31: 103744.
  • 22
    Orito E, Mizokami M, Sakugawa H et al. A case-control study for clinical and molecular biological differences between hepatitis B viruses of genotypes B and C. Hepatology 2001; 33: 21823.DOI: 10.1053/jhep.2001.20532
  • 23
    Takahashi K, Akahane Y, Hino K, Ohta Y, Mishiro S. Hepatitis B virus genomic sequence in the circulation of hepatocellular carcinoma patients: comparative analysis of 40 full-length isolates. Arch. Virol. 1998; 143: 231326.
  • 24
    Baptista M, Kramvis A, Kew MC. High prevalence of 1762(T) 1764 (A) mutations in the basic core promoter of hepatitis B virus isolated from black Africans with hepatocellular carcinoma compared with asymptomatic carriers. Hepatology 1999; 29: 94653.
  • 25
    Takahashi K, Aoyama K, Ohno N et al. The precore/core promoter mutant (T1762A1764) of hepatitis B virus: clinical significance and an easy method for detection. J. Gen. Virol. 1995; 76: 315964.
  • 26
    Kramvis A, Kew MC. The core promoter of hepatitis B virus. J. Viral Hepat. 1999; 6: 41527.DOI: 10.1046/j.1365-2893.1999.00189.x
  • 27
    Koike K. Hepatitis B virus HBx gene and hepatocarcinogenesis. Intervirology 1995; 38: 13442.
  • 28
    Kidd-Ljunggren K, Oberg M, Kidd AH. The hepatitis B virus X gene: analysis of functional domain variation and gene phylogeny using multiple sequences. J. Gen. Virol. 1995; 76: 211930.