Delta-F508 cystic fibrosis mutation is not linked to intussusception: Implications for rotavirus vaccine
Article first published online: 16 SEP 2003
Journal of Paediatrics and Child Health
Volume 39, Issue 7, pages 516–517, September 2003
How to Cite
Barnes, G., Srivastava, A., Carlin, J. and Francis, I. (2003), Delta-F508 cystic fibrosis mutation is not linked to intussusception: Implications for rotavirus vaccine. Journal of Paediatrics and Child Health, 39: 516–517. doi: 10.1046/j.1440-1754.2003.00204.x
- Issue published online: 16 SEP 2003
- Article first published online: 16 SEP 2003
- Accepted for publication10 November 2002.
- cystic fibrosis;
- delta-F508 mutation;
- rotavirus vaccine
Objective: To determine whether the cystic fibrosis (CF) delta-F508 gene mutation predisposes to intussusception, and so selects infants who should not receive rotavirus vaccine.
Methods: Stored neonatal screening blood spots, retrieved from 81 infants with intussusception and from 79 controls, were tested for the presence of the CF delta-F508 gene mutation.
Results: Prevalence of the mutation was similar in blood specimens from intussusception patients and from controls.
Conclusion: Testing for the CF delta-F508 mutation at birth is unlikely to identify infants predisposed to intussusception, and therefore is not relevant to rotavirus vaccine programs.