New concepts of cytokines in asthma: Is the Th2/Th1 paradigm out the window?
Article first published online: 21 OCT 2003
Journal of Paediatrics and Child Health
Volume 39, Issue 8, pages 575–579, November 2003
How to Cite
Prescott, S. (2003), New concepts of cytokines in asthma: Is the Th2/Th1 paradigm out the window?. Journal of Paediatrics and Child Health, 39: 575–579. doi: 10.1046/j.1440-1754.2003.00237.x
- Issue published online: 21 OCT 2003
- Article first published online: 21 OCT 2003
- Accepted for publication 23 June 2003.
- airway epithelium;
- Th2 responses
Abstract: Although asthma is clearly associated with a systemic propensity for allergic T helper type 2 (Th2) cell cytokine responses, independent local immune events appear to be responsible for the development of allergic airways inflammation. There is growing interest in how local immune networks interact with resident airway cell populations such as epithelial cells, which are now also recognized as key producers of cytokines, chemokines and growth factors. As well as their recognized role in airway remodelling, epithelial cells are now thought to have a role in initiating events. This review examines the role of cytokines produced by these and other cells in the development of asthma. It also highlights emerging concepts that the excessive and inappropriate immune responses seen in allergic disease may be related to dysfunction of various interleukin-10 producing regulatory cell populations.