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Keywords:

  • α-synuclein immunohistochemistry;
  • dementia with Lewy bodies;
  • diffuse Lewy body disease;
  • Lewy body;
  • Lewy body disease;
  • ubiquitin immunohistochemistry

With reports of dementia cases with numerous cortical Lewy bodies and our proposal that this be named ‘diffuse Lewy body disease’ (DLBD), this condition has received a great deal of attention, first in Japan and subsequently in Europe and North America. In the early 1990s, similar types of nomenclature were considered, and at the First International Workshop in 1995, it was proposed that ‘dementia with Lewy bodies’ be used as a generic term for Lewy body dementia, including the DLBD form. We review our previous clinicopathological findings and describe our recent immunohistochemical studies on DLBD.