Astroblastoma with unusual signet-ring-like cell components: A case report and literature review
Article first published online: 8 SEP 2008
Volume 22, Issue 3, pages 200–205, September 2002
How to Cite
Sugita, Y., Terasaki, M., Shigemori, M., Morimatsu, M., Honda, E. and Oshima, Y. (2002), Astroblastoma with unusual signet-ring-like cell components: A case report and literature review. Neuropathology, 22: 200–205. doi: 10.1046/j.1440-1789.2002.00435.x
- Issue published online: 8 SEP 2008
- Article first published online: 8 SEP 2008
- Received 17 September 2001; revised andaccepted 20 December 2001.
- intracytoplasmic vacuole;
- lipomatous differentiation;
- signet-ring-like cell
We report a case of astroblastoma with unusual signet-ring-like cell components. A 33-year-old-woman presented with occasional partial seizures of the face. Radiological studies revealed an enhanced frontal mass lesion. At surgery, a gray, soft, well-circumscribed mass was seen and shelled out. Histologically, the tumor showed a perivascular arrangement and papillary-like patterns with compact cellularity. The tumor cells radiating from the hyalinized vessels showed broader, shorter, less tapered processes. A part of each tumor cell displayed prominent islands of signet-ring-like cells. Glial fibrillary acidic protein reaction revealed strongly positive staining of tumor cells and signet-ring-like cells. Eight years after the operation the patient remains well with no tumor recurrence. It remains to be determined whether, in this astroblastoma, the unusual signet-ring-like cell components were related to benign biological characteristics or to the tumor's low-grade form with incidental signet-ring-like cell appearance.