Poor recovery sleep after sleep deprivation in delayed sleep phase syndrome

Authors

  • Makoto Uchiyama MD ,

    1. Department of Psychophysiology, National Institute of Mental Health, National Center of Neurology and Psychiatry, Ichikawa, Japan and,
    2. Department of Psychiatry, Kohnodai Hospital, National Center of Neurology and Psychiatry, Ichikawa, Japan
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  • Masako Okawa MD ,

    1. Department of Psychophysiology, National Institute of Mental Health, National Center of Neurology and Psychiatry, Ichikawa, Japan and,
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  • Kayo Shibui MD ,

    1. Department of Psychophysiology, National Institute of Mental Health, National Center of Neurology and Psychiatry, Ichikawa, Japan and,
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  • Keiko Kim MD ,

    1. Department of Psychophysiology, National Institute of Mental Health, National Center of Neurology and Psychiatry, Ichikawa, Japan and,
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  • Yosihisa Kudo MD ,

    1. Department of Psychophysiology, National Institute of Mental Health, National Center of Neurology and Psychiatry, Ichikawa, Japan and,
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  • Tatsuro Hayakawa MD ,

    1. Department of Psychiatry, Kohnodai Hospital, National Center of Neurology and Psychiatry, Ichikawa, Japan
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  • Yuichi Kamei MD ,

    1. Department of Psychiatry, Kohnodai Hospital, National Center of Neurology and Psychiatry, Ichikawa, Japan
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  • Jujiro Urata MD

    1. Department of Psychiatry, Kohnodai Hospital, National Center of Neurology and Psychiatry, Ichikawa, Japan
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Makoto Uchiyama MD, PhDDepartment of Psychophysiology, National Institute of Mental Health, NCNP, 1–7–3 Kohnodai, Ichikawa, 272 Japan.

Abstract

To clarify disturbances in sleep regulation in patients with delayed sleep phase syndrome (DSPS), we studied three patients with DSPS and seven healthy controls. Sleep propensity and melatonin rhythms after 24-h sleep deprivation were investigated under dim light condition by using the ultra-short sleep–wake schedule. The sleep propensity curves displayed clear differences between DSPS patients and the controls. During the subjective day when melatonin was not produced, recovery sleep after the sleep deprivation did not occur in DSPS patients, while recovery sleep occurred during the subjective day in controls. This suggests that DSPS may involve problems related to the homeostatic regulation of sleep after sleep deprivation.

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