Prenatal underdevelopment and schizophrenia: A case report of monozygotic twins
Article first published online: 2 MAY 2003
Psychiatry and Clinical Neurosciences
Volume 57, Issue 3, pages 271–274, June 2003
How to Cite
Kunugi, H., Urushibara, T., Murray, R. M., Nanko, S. and Hirose, T. (2003), Prenatal underdevelopment and schizophrenia: A case report of monozygotic twins. Psychiatry and Clinical Neurosciences, 57: 271–274. doi: 10.1046/j.1440-1819.2003.01116.x
- Issue published online: 2 MAY 2003
- Article first published online: 2 MAY 2003
- Received 26 June 2002; revised 7 November 2002; accepted 1 December 2002.
- hypoxic brain damage;
- low birthweight;
- perinatal complications;
- monozygotic twin;
Abstract A case is described herein of monozygotic twins discordant for schizophrenia that illustrates possible causal events of prenatal underdevelopment, morphological changes in the brain, poor premorbid functioning, and the development of schizophrenia. The affected twin was born with a birthweight of 1620 g, whereas the unaffected twin weighed 2300 g at birth. Marked differences in sociability and intelligence were observed between the twins from early childhood. Magnetic resonance imaging of the brain revealed high-intensity signals in the white matter and enlarged ventricles in the affected twin, while no such abnormality was detected in the well twin. This twin pair suggests a possibility that hypoxic brain damage associated with prenatal underdevelopment may be a causal factor for abnormalities in psychosocial development and subsequent schizophrenia.