Open pilot study of gabapentin versus trazodone to treat insomnia in alcoholic outpatients
Article first published online: 28 AUG 2003
Psychiatry and Clinical Neurosciences
Volume 57, Issue 5, pages 542–544, October 2003
How to Cite
Karam-Hage, M. and Brower, K. J. (2003), Open pilot study of gabapentin versus trazodone to treat insomnia in alcoholic outpatients. Psychiatry and Clinical Neurosciences, 57: 542–544. doi: 10.1046/j.1440-1819.2003.01161.x
- Issue published online: 28 AUG 2003
- Article first published online: 28 AUG 2003
- Received 5 November 2002; revised 3 February 2003; accepted 9 February 2003.
- drug therapy;
Alcohol-dependent outpatients with persisting insomnia were treated with either gabapentin or trazodone. Patients were assessed at baseline and after 4–6 weeks on medication using the Sleep Problems Questionnaire (SPQ). Of 55 cases initially treated, 9% dropped out due to morning drowsiness. Of the remaining 50 cases, 34 were treated with gabapentin (mean dose ± SD = 888 ± 418 mg) at bedtime and 16 were treated with trazodone (105 ± 57 mg) at bedtime. Both groups improved significantly on the SPQ but the gabapentin group improved significantly more than the trazodone group. Controlled studies are warranted to replicate these findings.