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Epithelioid trophoblastic tumor of the uterus: Cytological and immunohistochemical observation of a case
Article first published online: 5 APR 2002
DOI: 10.1046/j.1440-1827.2002.01313.x
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How to Cite
Kamoi, S., Ohaki, Y., Mori, O., Yokoyama, M., Kawamoto, Y., Kawamura, T. and Araki, T. (2002), Epithelioid trophoblastic tumor of the uterus: Cytological and immunohistochemical observation of a case. Pathology International, 52: 75–81. doi: 10.1046/j.1440-1827.2002.01313.x
Publication History
- Issue published online: 5 APR 2002
- Article first published online: 5 APR 2002
- Received 10 July 2001. Accepted for publication 5 October 2001
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Keywords:
- cytology;
- epithelioid trophoblastic tumor;
- immunohistochemistry
Epithelioid trophoblastic tumor (ETT) is a new entity of trophoblastic tumor and 14 such cases were reported by Shih and Kurman in 1998. However, only three subsequent cases supporting ETT have been reported. Recently, we experienced a case of ETT in a 37-year-old woman whose preoperative endometrial brushings showed atypical mononucleate giant cells and who underwent hysterectomy with the diagnosis of a uterine fibroid. The specimens revealed a 2.5 × 3.0 cm yellow–tan intramural nodule located in the lower uterine segment, which was composed of a neoplastic proliferation of intermediate trophoblasts in epithelioid arrangements. Immunohistochemically, the tumor cells were diffusely positive for cytokeratin and inhibin-α, and focally positive for human chorionic gonadotropin and human placental lactogen. She presented an uneventful clinical course as of September 2001.