Epithelioid trophoblastic tumor of the uterus: Cytological and immunohistochemical observation of a case


Seiryu Kamoi, MD, PhD, Department of Obstetrics and Gynecology, Nippon Medical School Chiba Hokusoh Hospital, 1715 Kamagari, Inba, Chiba 270-1694, Japan. Email: skamoi@nms.ac.jp


Epithelioid trophoblastic tumor (ETT) is a new entity of trophoblastic tumor and 14 such cases were reported by Shih and Kurman in 1998. However, only three subsequent cases supporting ETT have been reported. Recently, we experienced a case of ETT in a 37-year-old woman whose preoperative endometrial brushings showed atypical mononucleate giant cells and who underwent hysterectomy with the diagnosis of a uterine fibroid. The specimens revealed a 2.5 × 3.0 cm yellow–tan intramural nodule located in the lower uterine segment, which was composed of a neoplastic proliferation of intermediate trophoblasts in epithelioid arrangements. Immunohistochemically, the tumor cells were diffusely positive for cytokeratin and inhibin-α, and focally positive for human chorionic gonadotropin and human placental lactogen. She presented an uneventful clinical course as of September 2001.