Uroguanylin level in umbilical cord blood
Version of Record online: 23 DEC 2001
Volume 43, Issue 3, pages 267–269, June 2001
How to Cite
Tsukahara, H., Sekine, K., Uchiyama, M., Miura, M., Nakazato, M., Date, Y., Tsunezawa, W., Kotsuji, F., Nishida, K., Hiraoka, M. and Mayumi, M. (2001), Uroguanylin level in umbilical cord blood. Pediatrics International, 43: 267–269. doi: 10.1046/j.1442-200x.2001.01393.x
- Issue online: 23 DEC 2001
- Version of Record online: 23 DEC 2001
- natriuretic peptide;
- umbilical cord blood;
Abstract Background: Uroguanylin is a novel natriuretic and diuretic peptide originally isolated from urine.
Methods: To determine whether uroguanylin has a physiologic role during the perinatal period, uroguanylin levels in umbilical cord plasma obtained at the time of delivery were measured by radioimmunoassay and compared with cord serum osmolality.
Results: Mean (±SD) cord plasma uroguanylin concentrations (8.8±2.1 fmol/mL) were higher compared with normal adult values. The extent of maturity, mode of delivery and gender did not appear to influence cord uroguanylin levels. The uroguanylin concentration had a significant positive correlation with cord serum osmolality.
Conclusion: These findings support some regulatory role of this peptide in perinatal renal and cardiovascular adaptation.