Transperineal 12-core systematic biopsy in the detection of prostate cancer
Article first published online: 21 DEC 2001
International Journal of Urology
Volume 8, Issue 6, pages 301–307, June 2001
How to Cite
Kojima, M., Hayakawa, T., Saito, T., Mitsuya, H. and Hayase, Y. (2001), Transperineal 12-core systematic biopsy in the detection of prostate cancer. International Journal of Urology, 8: 301–307. doi: 10.1046/j.1442-2042.2001.00303.x
- Issue published online: 21 DEC 2001
- Article first published online: 21 DEC 2001
The present study was designed to determine the clinical value of transperineal 12-core systematic prostate biopsy guided by transrectal ultrasonography (TRUS) in the detection of prostate cancer.
A total of 679 consecutive patients underwent systematic prostate biopsies because of abnormal results on digital rectal examination and/or TRUS and/or an elevated serum prostate-specific antigen level. Systematic six- and 12-core biopsies were taken in 138 patients between April 1994 and February 1995 and in the remaining 541 between March 1995 and February 2000, respectively. Twelve-core biopsy included two samples from the lateral portion of the peripheral zone and four from the anterior portion of the transition zone in addition to the conventional six-core biopsy.
In the series overall, systematic biopsy revealed 156 cases of prostate cancer (23.0%). The detection rate increased by 5.2%, although this was statistically not significant, from 18.8% (26/138) by six-core biopsy to 24.0% (130/541) by 12-core biopsy. Out of 130 patients in whom prostate cancer was detected by 12-core biopsy, it was supposed that conventional six-core biopsy would have missed 18 cases (13.8%).
Systematic 12-core biopsy might improve the detection rate for prostate cancer. However, further studies are needed to determine its clinical value in the diagnosis of the disease.