Urinary transforming growth factor-β1 levels correlate with bladder outlet obstruction


Correspondence: Manoj Monga MD, Division of Urology (8897), UCSD Medical Center, 200 West Arbor Drive, San Diego, CA 92103–8897, USA. Email: mmonga@ucsd.edu


Abstract Background: Urinary transforming growth factor-β1 (TGF-β1) levels have been shown to correlate with elevated intrapelvic pressure associated with ureteropelvic junction obstruction. Other studies have evaluated urinary TGF-β1 levels in prostate cancer. This study tests the hypothesis that urinary TGF-β1 levels might correlate with objective measures of bladder outlet obstruction (BOO).

Methods: Twenty-three men (age: 46–85 years) with lower urinary tract symptoms underwent urodynamic studies consisting of non-invasive uroflowmetry, cystometrogram and voiding pressure flow studies. Patients were classified as obstructed (n = 17) or not obstructed (n = 6) based on Abrams-Griffith nomograms. Urinary TGF-β1 was extracted from an aliquot of urine obtained at the time of bladder catheterization for urodynamic studies. Urinary TGF-β1 levels were then determined by enzyme-linked immunosorbent assay (ELISA).

Results: There was a strong correlation between urinary TGF-β1 levels and the presence of obstruction by Abrams-Griffith nomogram criteria (P = 0.025). Urinary TGF-β1 levels were significantly higher in men with obstruction (0.039 ± 0.011 pg/mL) than in men without obstruction (0.029 ± 0.009 pg/mL; P = 0.036).

Conclusion: Urinary TGF-β1 levels correlate with objective measures of BOO. Further study is needed to test the utility of urinary TGF-β1 as a non-invasive diagnostic tool for BOO.