Clinical findings and risk factors for Candida esophagitis in outpatients*


  • *

    Published as an abstract: Underwood J A, Keate R F, Williams J W. Clinical findings and risk factors for Candida esophagitis in out-patients. Am J Gastroenterol 1998; 93: 1628.

Address correspondence to: Dr R F Keate, Memorial Regional Medical Center, 8220 Meadowbridge Road, Suite 311, Mechanicsville, Virginia 23116, USA.


SUMMARY We retrospectively reviewed 18 patients with endoscopically discovered Candida esophagitis to more fully characterize this entity and identify predisposing conditions. Candida esophagitis was defined by the presence of fungal mycelia on brush cytology. Only two patients had an associated malignancy. Other possible predisposing risk factors were acid suppressive therapy (14 patients), prior gastric surgery (five), mucosal barrier injury (four), inhaled steroid use (four), oral steroid use (three), esophageal motility disorders (three), rheumatologic disorders (three), prior antibiotic use (two) and diabetes mellitus (two). The majority of patients had more than one proposed risk factor. Ten (56%) were treated with antifungal therapy. Thus, Candida esophagitis was infrequently seen in patients with associated malignancy. Prospective evaluation of predisposing conditions and treatment is recommended.