Get access

Melanoma-associated retinopathy: does autoimmunity prolong survival?


Correspondence: Dr Colin Chan The Royal Victorian Eye and Ear Hospital, 32 Gisborne Street, East Melbourne, Victoria 3002, Australia. Email:


Purpose: To discuss the autoimmune basis of melanoma-associated retinopathy (MAR) and its implications for management and prognosis.

Methods: An unusual history of a woman with melanoma-associated retinopathy is presented in detail. A review of published reports and a summary of 19 reported cases of MAR provide a basis for discussion.

Results: This case report and other published reports highlight a number of points regarding MAR including the male predominance, prolonged survival in several patients and lack of response to immunosuppression.

Conclusions: Melanoma-associated retinopathy may prolong the survival of patients with metastatic melanoma through the autoimmune response. Therefore, treatment of visual symptoms with immunosuppression needs to be considered carefully.

Get access to the full text of this article