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Melanoma-associated retinopathy: does autoimmunity prolong survival?

Authors


Correspondence: Dr Colin Chan The Royal Victorian Eye and Ear Hospital, 32 Gisborne Street, East Melbourne, Victoria 3002, Australia. Email: chunkeng@yahoo.com

ABSTRACT

Purpose: To discuss the autoimmune basis of melanoma-associated retinopathy (MAR) and its implications for management and prognosis.

Methods: An unusual history of a woman with melanoma-associated retinopathy is presented in detail. A review of published reports and a summary of 19 reported cases of MAR provide a basis for discussion.

Results: This case report and other published reports highlight a number of points regarding MAR including the male predominance, prolonged survival in several patients and lack of response to immunosuppression.

Conclusions: Melanoma-associated retinopathy may prolong the survival of patients with metastatic melanoma through the autoimmune response. Therefore, treatment of visual symptoms with immunosuppression needs to be considered carefully.

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