Get access

Preventative effect of deferoxamine on degenerative changes in the optic nerve in experimental retrobulbar haematoma

Authors

  • Aysel Pelit MD,

    1. 1 Ophthalmology Department, Baskent University, Departments of 2 Ophthalmology, 3 Pathology and 4Histology, Çukurova University, and 5Medical Sciences Experimental Research and Practice Center, Çukurova University, Adana, Turkey
    Search for more papers by this author
  • 1 Gülhanim Haciyakupoglu MD,

    1. 1 Ophthalmology Department, Baskent University, Departments of 2 Ophthalmology, 3 Pathology and 4Histology, Çukurova University, and 5Medical Sciences Experimental Research and Practice Center, Çukurova University, Adana, Turkey
    Search for more papers by this author
  • 2 Suzan Zorludemir MD,

    1. 1 Ophthalmology Department, Baskent University, Departments of 2 Ophthalmology, 3 Pathology and 4Histology, Çukurova University, and 5Medical Sciences Experimental Research and Practice Center, Çukurova University, Adana, Turkey
    Search for more papers by this author
  • 3 Ufuk Mete MD,

    1. 1 Ophthalmology Department, Baskent University, Departments of 2 Ophthalmology, 3 Pathology and 4Histology, Çukurova University, and 5Medical Sciences Experimental Research and Practice Center, Çukurova University, Adana, Turkey
    Search for more papers by this author
  • 4 Kenan Daglioglu PhD,

    1. 1 Ophthalmology Department, Baskent University, Departments of 2 Ophthalmology, 3 Pathology and 4Histology, Çukurova University, and 5Medical Sciences Experimental Research and Practice Center, Çukurova University, Adana, Turkey
    Search for more papers by this author
  • and 5 Mehmet Kaya PhD 4

    1. 1 Ophthalmology Department, Baskent University, Departments of 2 Ophthalmology, 3 Pathology and 4Histology, Çukurova University, and 5Medical Sciences Experimental Research and Practice Center, Çukurova University, Adana, Turkey
    Search for more papers by this author

Dr Aysel Pelit, Baskent Üniversitesi Tip Fakultesi, Adana Uyg. Ve Arast. Hastanesi, Göz ABD, Dadaloglu mah. 39, sok No: 6, Yüregir, Adana 01250, Turkey. Email: apelit@mail.cu.edu.tr

Abstract

Purpose: Changes in the optic nerve due to the breakdown of blood elements and the effect of deferoxamine on these changes were evaluated.

Methods: The study group consisted of 12 rabbits. Three rabbits were used as control. In Group I, three rabbits had bilateral retrobulbar haematoma induced. In Group II, three rabbits had bilateral retrobulbar haematoma induced and were given systemic deferoxamine. In Group III, three rabbits were only given deferoxamine. At day 21, all the rabbits underwent bilateral enucleation and specimens from the orbital fat tissue were removed for light microscopic examination. The optic nerves were examined by light and electron microscopy.

Results: Light microscopic examination of the optic nerves did not reveal significant differences among the groups. Electron microscopy revealed ultrastructural changes in Group I. There were no significant pathological findings observed in Groups II or III. There was abundant iron pigment in the orbital fat tissue of Group I, but only a small amount in Group II.

Conclusion: Systemic deferoxamine treatment is effective in preventing degenerative changes in retrobulbar haema­toma.

Ancillary