Presented in part at the Canadian Ocular Pathology Study Group meeting, Halifax, Nova Scotia, Canada, 25 June 1999.
Pathogenesis of orbital cholesterol granuloma
Article first published online: 12 FEB 2003
Clinical & Experimental Ophthalmology
Volume 31, Issue 1, pages 78–82, February 2003
How to Cite
Selva, D., Phipps, S. E., O'Connell, J. X., White, V. A. and Rootman, J. (2003), Pathogenesis of orbital cholesterol granuloma. Clinical & Experimental Ophthalmology, 31: 78–82. doi: 10.1046/j.1442-9071.2003.00605.x
- Issue published online: 12 FEB 2003
- Article first published online: 12 FEB 2003
- cholesterol granuloma;
- fibrous dysplasia;
- frontal bone;
- osteolytic lesion
Two cases are presented of orbital cholesterol granuloma associated with gradual proptosis arising in men aged 35 and 41 years. Computed tomography demonstrated osteolytic masses in the frontal bone at the lacrimal fossa. Curettage revealed a characteristic histology of foreign body reactions surrounding cholesterol clefts. In both cases abnormal bone, more consistent with fibrous dysplasia than reactive change, was found at the periphery. The finding of abnormal bone associated with orbital cholesterol granulomas suggests that a pre-existing bone anomaly may be present in a subset of these cases.