The Twilight Zone of Troponins

Authors


Hendrik Zimmet, Flinders Medical Centre, Flinders Drv, Bedford Park, South Australia 5042, Australia. Email: hzimmet@yahoo.com

Abstract

Since its introduction into the clinical environment in the early nineties, the cardiac enzyme troponin has significantly changed the way we diagnose and manage acute coronary syndromes. Troponin I is a biochemical marker of myocardial injury with a high level of specificity and sensitivity. It has been demonstrated that as ischaemia progresses, troponin I is degraded predictably into smaller and smaller fragments that can be detected in the blood-stream. This may eventually allow more accurate determination of the duration of ischaemia and the likelihood of myocardial salvage and recovery. (Heart, Lung and Circulation 2003; 12: S90−S94)

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