Association of amino acid variation (Trp64Arg) in the beta3-adrenergic receptor gene with bone mineral density
Article first published online: 7 NOV 2002
Geriatrics & Gerontology International
Volume 2, Issue 3, pages 138–142, September 2002
How to Cite
Ogawa, S., Emi, M., Shiraki, M., Hosoi, T., Orimo, H., Ouchi, Y. and Inoue, S. (2002), Association of amino acid variation (Trp64Arg) in the beta3-adrenergic receptor gene with bone mineral density. Geriatrics & Gerontology International, 2: 138–142. doi: 10.1046/j.1444-1586.2002.00037.x
- Issue published online: 7 NOV 2002
- Article first published online: 7 NOV 2002
- Accepted for publication 24 July 2002.
- beta3-adrenergic receptor;
Background: Recent studies have revealed that a mis-sense mutation replacing tryptophan with arginine at codon 64 (Trp64Arg) of the beta3-adrenergic receptor (β3-AR) gene was associated with insulin resistance in non-diabetic subjects and to earlier onset of non-insulin dependent diabetes mellitus. To analyze a possible involvement of β3-AR in bone metabolism, we investigated the association between bone mineral density (BMD) and the Trp64Arg polymorphism.
Methods: A large cohort of Japanese postmenopausal women comprised the study population. The genotypic frequencies in this cohort were Trp/Trp, 61.8%; Trp/Arg, 33.2%; and Arg/Arg, 5.0%.
Results: When the subjects were separated into two groups, one bearing at least one Trp allele at codon 64 (Trp/Trp and Trp/Arg) and the other with none (Arg/Arg), the former subjects had significantly higher Z scores for total-body BMD (mean ± SD, 0.432 ± 0.93 versus −0.135 ± 0.93; P = 0.033).
Conclusions: These data suggested an association between this single-nucleotide polymorphism (SNP) in the β3-AR gene and BMD, and therefore a possible involvement of the Arg allele (or the absence of Trp64) in postmenopausal osteoporosis among Japanese women.