Nitric oxide, induced by kainate application, regulates norepinephrine release in the laterodorsal tegmental nucleus of rats
Article first published online: 10 JUN 2003
Sleep and Biological Rhythms
Volume 1, Issue 2, pages 107–109, June 2003
How to Cite
KODAMA, T., HONDA, Y. and KOYAMA, Y. (2003), Nitric oxide, induced by kainate application, regulates norepinephrine release in the laterodorsal tegmental nucleus of rats. Sleep and Biological Rhythms, 1: 107–109. doi: 10.1046/j.1446-9235.2003.00013.x
- Issue published online: 10 JUN 2003
- Article first published online: 10 JUN 2003
- Accepted for publication 24 January 2003.
- cyclic guanine monophosphate;
- nitric oxide;
Nitric oxide (NO) released from the cholinergic neurons may play important roles in sleep-wake regulation. We reported a possible role of NO, which was mediated through n-methyl-d-aspartic acid (NMDA) receptors in the cholinergic neurons in pons, as a retrograde regulator of norepinephrine (NE) release from the locus coeruleus neurons. In this study, we further investigate the effect of kainate application. There were significant increases in concentration of NO (P < 0.05) for 20 min, in NE (P < 0.05) for 15 min, and in cyclic guanine monophosphate (cGMP; P < 0.05) for 60 min after the initiation of kainate application (5 mmol/L). The difference in the distributions of NMDA and kainate receptors in the dorsolateral pontine tegmental nucleus (LDT) may explain the different firing patterns of LDT neurons.