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Cerebrospinal fluid-orexin decreases during intraventricular α-interferon therapy of the patients with subacute sclerosing panencephalitis


Dr Y Ogawa, Department of Neuropsychiatry, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan. Email:


We determined the orexin concentration in cerebrospinal fluid (CSF-OX) in two patients with subacute sclerosing panencephalitis who underwent intracerebroventricular (ICV) α-interferon (IFN-α) therapy. In these patients, CSF-OX were in the normal range before ICV administration of IFN-α, and it decreased to undetectable levels after the initiation of IFN-α therapy. It was reported that the production of prepro-OX, which is a precursor of OX, was prevented when IFN-α was given to the gene promoter region of prepro-OX. These results suggest that the production of OX may be suppressed by inhibition of promotor activity when IFN-α is given to the cerebral ventricle in humans.