Levels of hypocretin-1 (orexin A) in the cerebrospinal fluid of two young hypersomniacs suspected of being narcoleptic
Article first published online: 10 JUN 2003
Sleep and Biological Rhythms
Volume 1, Issue 2, pages 167–168, June 2003
How to Cite
URAKAMI, T., KURODA, K., KANBAYASHI, T., EMURA, N., MANDAI, M., MATSUMURA, H., YOSHIDA, Y., NISHINO, S. and YONEDA, H. (2003), Levels of hypocretin-1 (orexin A) in the cerebrospinal fluid of two young hypersomniacs suspected of being narcoleptic. Sleep and Biological Rhythms, 1: 167–168. doi: 10.1046/j.1446-9235.2003.00034.x
- Issue published online: 10 JUN 2003
- Article first published online: 10 JUN 2003
- Accepted for publication 18 October 2002.
- hypocretin-1 (orexin A);
The level of hypocretin-1 (orexin A) is reported to be low in the cerebrospinal fluid (CSF) of subjects with narcolepsy. We measured the CSF level of hypocretin-1 of two young hypersomniacs. The first subject was a 9-year-old boy who exhibited cataplexy, and was demonstrated to be human leukocyte antigen-DR2 (HLA-DR2) positive. The second subject was a 16-year-old boy who exhibited no cataplexy and was HLA-DR2 negative. When excessive daytime sleepiness ensued, appetite and bodyweight were increased in case 1 but not in case 2. The level of CSF hypocretin-1 was undetectably low and within normal limits in case 1 and case 2, respectively. It appears to be important to measure the CSF level of hypocretin-1 in the diagnosis and treatment of narcolepsy.