Present address: Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA.
Long-term potentiation of glutamatergic synaptic transmission induced by activation of presynaptic P2Y receptors in the rat medial habenula nucleus
Article first published online: 25 FEB 2003
European Journal of Neuroscience
Volume 17, Issue 4, pages 844–850, February 2003
How to Cite
Price, G. D., Robertson, S. J. and Edwards, F. A. (2003), Long-term potentiation of glutamatergic synaptic transmission induced by activation of presynaptic P2Y receptors in the rat medial habenula nucleus. European Journal of Neuroscience, 17: 844–850. doi: 10.1046/j.1460-9568.2003.02501.x
- Issue published online: 25 FEB 2003
- Article first published online: 25 FEB 2003
- Received 10 September 2002, revised 3 December 2002, accepted 5 December 2002
- uridine nucleotides
A novel form of long-term potentiation of glutamatergic synaptic transmission is described in the rat medial habenula nucleus. It occurs when uridine 5′-triphosphate is bath applied at low micromolar concentrations and is prevented by Reactive Blue 2, suggesting that it is mediated by P2Y4 receptors. Uridine 5′-diphosphate can also cause such a Reactive Blue 2-sensitive potentiation, but at higher concentrations (200 µm), suggesting that this might also be an effect on the relatively uridine 5′-diphosphate-insensitive P2Y4 receptor. The potentiation is due to an increase in presynaptic release probability. It requires neither depolarization nor calcium influx postsynaptically and is thus probably non-Hebbian. When potentiation due to low concentrations of uridine 5′-triphosphate is inhibited in the presence of Reactive Blue 2, uridine 5′-triphosphate causes instead a significant inhibition of glutamate release. We suggest that this inhibition may be mediated by a Reactive Blue 2-insensitive P2Y2-like receptor. At higher concentrations of uridine 5′-triphosphate (200 µm), the inhibitory effect dominates such that even in the absence of Reactive Blue 2 no potentiation is seen.