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Systemic or intra-amygdala injections of glucose facilitate memory consolidation for extinction of drug-induced conditioned reward

Authors


: Dr M. Packard, as above.
E-mail: mgp@psyc.tamu.edu

Abstract

The conditioned place preference (CPP) task has been used extensively to investigate the neurobiological bases of drug-induced reward. The initial expression of a CPP involves memory for an association between environmental stimuli and the affective state produced by a rewarding treatment. The present experiments examined the hypothesis that post-trial administration of glucose can facilitate memory consolidation processes underlying the extinction of drug-induced CPP behaviour. Adult male Long-Evans rats acquired an amphetamine CPP, and subsequently received extinction training. Immediately following extinction training, separate groups of rats received peripheral (100 mg/kg, 500 mg/kg, or 2 g/kg) or intra-amygdala (basolateral nucleus; 1.5 µg/0.5 µL or 10 µg/0.5 µL) injections of glucose or vehicle. Peripheral (100 mg/kg and 2 g/kg) and intra-amygdala (1.5 and 10 µg) glucose injections facilitated the extinction of amphetamine CPP behaviour relative to vehicle-injected controls. Postextinction trial peripheral or intra amygdala glucose injections that were delayed 2 h had no effect. The findings indicate that: (i) extinction of approach behaviour to drug-associated cues involves the formation of new memories that undergo a time-dependent consolidation process; and (ii), systemic or intra-amygdala administration of a known memory-enhancing agent facilitates extinction of drug-induced CPP behaviour.

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