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Keywords:

  • β-adrenoceptor;
  • CA1;
  • hippocampus;
  • long-term memory;
  • d,l-propranolol;
  • rat

Abstract

The present study investigated the effects of intra-CA1 infusion of d,l-propranolol, the β-adrenergic antagonist, on memory for contextual fear conditioning. d,l-Propranolol administered 5 min (‘0 h’) postconditioning impaired long-term but not short-term contextual fear memory, while it was ineffective when administered 6 h postconditioning, suggesting that there is a time window for β-adrenoceptors to play a role. Thus, we conclude that β-adrenoceptors in area CA1 are involved in regulating consolidation of contextual fear memory, with ‘0 h’ but not 6 h post-training, a sensitive time point for the β-adrenergic involvement.