Retracted: Prophylactic therapy with granisetron in the prevention of vomiting after paediatric surgery. A randomized, double-blind comparison with droperidol and metoclopramide
Version of Record online: 4 JAN 2002
1997 Blackwell Science Ltd.
Volume 8, Issue 2, pages 149–153, 1998-03
How to Cite
FUJII, Y. and TANAKA, H. (1998), Retracted: Prophylactic therapy with granisetron in the prevention of vomiting after paediatric surgery. A randomized, double-blind comparison with droperidol and metoclopramide. Pediatric Anesthesia, 8: 149–153. doi: 10.1046/j.1460-9592.1998.00761.x
- Issue online: 4 JAN 2002
- Version of Record online: 4 JAN 2002
Vol. 22, Issue 12, 1235, Version of Record online: 21 OCT 2012
- Cited By
- complications: vomiting;
- droperidol, metoclopramide, granisetron
The antiemetic efficacy of droperidol, metoclopramide and granisetron was compared with placebo in the reduction of vomiting after paediatric surgery (the extremities; inguinal hernia; and phimosis) during general inhalational anaesthesia. One hundred children, ASA physical status I, 4–10 years of age, were enrolled in a prospectively, randomized, double-blind investigation and assigned to one of four treatment regimens: placebo (saline, n=25), droperidol (50 μg·kg1, n=25), metoclopramide (0.25 mg·kg-1, n=25) or granisetron (40 μg·kg-1, n=25). These drugs were administered intravenously (iv) after inhalation induction of anaesthesia. A complete response, defined as no emesis and no need for another rescue antiemetic during the first 24 h after anaesthesia, occurred in 60%, 76%, 68% and 88% of patients who had received placebo, droperidol, metoclopramide and granisetron, respectively (P<0.05; overall Fisher's exact probability test). The incidence of adverse events postoperatively was not different among the treatment groups. In conclusion, granisetron 40 μg·kg-1 is a better antiemetic than droperidol and metoclopramide when compared to placebo for the prevention of postoperative emesis in children.