• Aliprantis, A.O., Yang, R.B., Mark, M.R., Suggett, S., Devaux, B. & Radolf, J.D. et al. (1999) Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science 285: 736739.DOI: 10.1126/science.285.5428.736
  • Faure, E., Equils, O., Sieling, P.A., Thomas, L., Zhang, F.X. & Kirschning, C.J. et al. (2000) Bacterial lipopolysaccharide activates NF-kappaB through toll-like receptor 4 (TLR-4) in cultured human dermal endothelial cells. Differential expression of TLR-4 and TLR-2 in endothelial cells. J Biol Chem 275: 1105811063.
  • Hedlund, M., Svensson, M., Nilsson, A., Duan, R.D. & Svanborg, C. (1996) Role of the ceramide-signaling pathway in cytokine responses to P-fimbriated Escherichia coli. J Exp Med 183: 10371044.
  • Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T. & Takeda, Y. et al. (1999) Cutting edge: toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162: 37493752.
  • Janeway, C.A., Jr (1989) Approaching the asymptote? Evolution and revolution in immunology. C Spring Harb Symp Quant Biol 54 (1): 113.
  • Janeway, C.A., Travers, P., Walport, M. & Capra, J.D. (1999) Antigens in immunologically privileged sites do not induce immune attack but can serve as targets. In Immunobiology: the Immune System in Health and Disease. London: Current Biology Publications, pp. 525527.
  • Karow, M. & Georgopoulos, C. (1992) Isolation and characterization of the Escherichia coli msbB gene, a multicopy suppressor of null mutations in the high-temperature requirement gene htrB. J Bacteriol 174: 702710.
  • Khan, S.A., Everest, P., Servos, S., Foxwell, N., Zahringer, U. & Brade, H. et al. (1998) A lethal role for lipid A in Salmonella infections. Mol Microbiol 29: 571579.
  • Low, K.B., Ittensohn, M., Le, T., Platt, J., Sodi, S. & Amoss, M. et al. (1999) Lipid A mutant Salmonella with suppressed virulence and TNFalpha induction retain tumor-targeting in vivo. Nat Biotechnol 17: 3741.DOI: 10.1038/5205
  • Martinez, J.J., Mulvey, M.A., Schilling, J.D., Pinkner, J.S. & Hultgren, S.J. (2000) Type 1 pilus-mediated bacterial invasion of bladder epithelial cells. Embo J 19: 28032812.DOI: 10.1093/emboj/19.12.2803
  • Medzhitov, R. & Janeway, C.A., Jr (1997) Innate immunity: the virtues of a nonclonal system of recognition. Cell 91: 295298.
  • Medzhitov, R., Preston-Hurlburt, P. & Janeway, C.A., Jr (1997) A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388: 394397.DOI: 10.1038/41131
  • Mulvey, M.A., Lopez-Boado, Y.S., Wilson, C.L., Roth, R., Parks, W.C., Heuser, J. & Hultgren, S.J. (1998) Induction and evasion of host defenses by type 1-piliated uropathogenic Escherichia coli. Science 282: 14941497.
  • Ogata, H., Su, I., Miyake, K., Nagai, Y., Akashi, S. & Mecklenbrauker, I. et al. (2000) The Toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells. J Exp Med 192: 2330.
  • Poltorak, A., He, X., Smirnova, I., Liu, M.Y., Huffel, C.V. & Du, X. et al. (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282: 20852088.
  • Rock, F.L., Hardiman, G., Timans, J.C., Kastelein, R.A. & Bazan, J.F. (1998) A family of human receptors structurally related to Drosophila Toll. Proc Natl Acad Sci USA 95: 588593.DOI: 10.1073/pnas.95.2.588
  • Soderhall, M., Bergerheim, U.S., Jacobson, S.H., Lundahl, J., Mollby, R., Normark, S. & Winberg, J. (1997) Molecular evidence for pap-G specific adhesion of Escherichia coli to human renal cells. J Urol 157: 346350.
  • Sokurenko, E.V., Hasty, D.L. & Dykhuizen, D.E. (1999) Pathoadaptive mutations: gene loss and variation in bacterial pathogens. Trends Microbiol 7: 191195.DOI: 10.1016/s0966-842x(99)01493-6
  • Somerville, J.E.Jr, Cassiano, L., Bainbridge, B., Cunningham, M.D. & Darveau, R.P. (1996) A novel Escherichia coli lipid A mutant that produces an antiinflammatory lipopolysaccharide. J Clin Invest 97: 359365.
  • Takeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H. & Ogawa, T. et al. (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11: 443451.
  • Uhlén, P., Laestadius, A., Jahnukainen, T., Soderblom, T., Bäckhed, F. & Celsi, G. et al. (2000) Alpha-haemolysin of uropathogenic E. coli induces Ca2+ oscillations in renal epithelial cells. Nature 405: 694697.DOI: 10.1038/35015091
  • Underhill, D.M., Ozinsky, A., Hajjar, A.M., Stevens, A., Wilson, C.B., Bassetti, M. & Aderem, A. (1999) The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 401: 811815.DOI: 10.1038/44605
  • Zhang, F.X., Kirschning, C.J., Mancinelli, R., Xu, X.P., Jin, Y. & Faure, E. et al. (1999) Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes. J Biol Chem 274: 76117614.