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Leptin concentrations are related to glycaemic control, but do not change with short-term oral antidiabetic therapy in female patients with type 2 diabetes mellitus


  • Note: This paper is presented as a poster under the title of Relation of leptin with metabolic parameters in female patients with non-insulin-dependent diabetes mellitus’, at the 35th annual meeting of the EASD held in Brussels between 28 September and 2 October 1999.

Serdar Güler, Ulucanlar Caddesi, 68/5 Cebeci 06590, Ankara, Turkey.


This study evaluated the relation of leptin with glycaemic control and the effect of 14 days of diet, or diet combined with gliclazide, glipizide-GITS or metformin treatment, on leptin concentration in 51 female patients with type 2 diabetes mellitus. Leptin levels were similar both at baseline and after treatment in diabetic and control groups. Diabetic patients with basal fasting plasma glucose (FPG) < 10 mmol/l or with basal postprandial plasma glucose (PPPG) < 13.9 mmol/l had significantly higher leptin levels than diabetic patients with basal FPG ≥ 10 mmol/l or with basal PPPG ≥ 13.9 mmol/l (19.6 ± 8.7 vs. 13.65 ± 5.4 μg/l, p < 0.05; and 20.2 ± 7.9 vs. 12.9 ± 5.2 μg/l, p < 0.05, respectively). Mode of treatment did not influence leptin levels. Δ leptin showed a weak correlation with basal FPG (r = 0.346; p < 0.05), basal and post-treatment PPPG (r = 0.335, p < 0.05 and r = 0.325, p < 0.05, respectively) and a moderate correlation with post-treatment FPG (r = 0.391, p < 0.01). In conclusion, leptin level is not affected by the presence of type 2 diabetes mellitus and by short-term treatment with diet or oral antidiabetic drugs but is directly related to glycaemic control in female patients with type 2 diabetes mellitus.

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