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Variations in plasma soluble tumour necrosis factor receptors after diet-induced weight loss in obesity


Dr Jean-Philippe Bastard, MD, PhD, Service de Biochimie et Hormonologie, Hôpital Tenon, 4 rue de la Chine, 75970, Paris Cedex 20, France.


The aim of this study was to investigate the variations in the plasma levels of the soluble tumour necrosis factor receptor type-I (sTNFR-I) and type-II (sTNFR-II) during weight loss which was induced by 3 weeks on a very low calorie diet (3.9 ± 0.1 MJ/day), in 17 non-diabetic obese women. Plasma sTNFR-I concentrations decreased significantly after weight loss (p < 0.05), but there was no significant change in plasma sTNFR-II. As the diet was associated with a significant decrease in body fat mass (≈2.5 kg), this result supports the emerging concept that adipose tissue can produce significant amounts of sTNFR-I and that this production can be modified by weight loss in human obesity