The relationship of circulating insulin-like growth factor 1, its binding protein-3, prostate-specific antigen and C-reactive protein with disease stage in prostate cancer
Article first published online: 28 FEB 2002
Volume 89, Issue 4, pages 396–399, March 2002
How to Cite
Latif, Z., McMillan, D.C., Wallace, A.M., Sattar, N., Mir, K., Jones, G. and Underwood, M.A. (2002), The relationship of circulating insulin-like growth factor 1, its binding protein-3, prostate-specific antigen and C-reactive protein with disease stage in prostate cancer. BJU International, 89: 396–399. doi: 10.1046/j.1464-4096.2001.01641.x
- Issue published online: 28 FEB 2002
- Article first published online: 28 FEB 2002
- Accepted for publication 1 December 2001
- prostate cancer;
- C-reactive protein
Objective To assess the relationships among circulating insulin-like growth factor-1 (IGF-1), IGF binding protein-3 (IGFBP-3), prostate-specific antigen (PSA) and C-reactive protein (an indicator of inflammatory systemic response) in patients with prostate disease and cancer of different stages.
Patients and methods Circulating IGF-1, IGFBP-3, PSA and C-reactive protein concentrations were measured in patients with BPH (17) or stages T1/T2 (15), T3/T4 (16) and metastatic prostate cancer (12 patients).
Results IGF-1 and IGFBP-3 concentrations were similar between patients with BPH and those with cancer, and there was no difference between the groups with cancer. In the latter patients there was a significant correlation between age and IGFBP-3 concentrations (r = − 0.400, P = 0.008) but not with IGF-1 concentrations. Controlling for age, there were significant partial correlations between C-reactive protein and IGF-1 (r = − 0.412, P = 0.008) and IGFBP-3 (r = − 0.277, P = 0.05).
Conclusions These results indicate that circulating IGF-1 and IGFBP-3 concentrations do not change with disease stage in prostate cancer, but that they decrease with an increase in the systemic inflammatory response.