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References

  • 1
    Mills TM, Reilly CM, Lewis RW. Androgens and penile erection: a review. J Androl 1996; 17: 6338
  • 2
    Baskin LS, Sutherland RS, DiSandro MJ, Hayward SW, Lipschultz J, Cunha GR. The effect of testosterone on androgen receptors and human penile growth. J Urol 1997; 158: 11138
  • 3
    Shabsigh R. The effects of testosterone on the cavernous tissue and erection. World J Urol 1997; 15: 216
  • 4
    Yildrim MK, Yildrim S, Utkan T, Sarioglu Y, Yalman Y. Effects of castration on adrenergic, cholinergic and nonadrenergic, noncholinergic responses of isolated corpus cavernosum from rabbit. Br J Urol 1997; 79: 96470
  • 5
    Rousseau L, Dupont A, Labrie F, Couture M. Sexuality changes in prostate cancer patients receiving antihormonal therapy combining the antiandrogen flutamide with medical (LHRH agonist) or surgical castration. Arch Sex Behav 1988; 17: 8798
  • 6
    Schiavi RC, Schreiner-Engel P, Mandeli J, Schanzer H, Cohen E. Healthy aging and male sexual function. Am J Psychiatr 1990; 147: 76671
  • 7
    Davidson JM, Chen JJ, Crapo L, Gray GD, Greenleaf WJ, Catania JA. Hormonal changes and sexual function in aging men. J Clin Endocrinol Metab 1983; 57: 717
  • 8
    Schiavi RJ. Androgens and male sexual function in man. In OddensB, VermeulenA eds, Androgens and the Aging Male. Amsterdam: Parthenon, 1993: 11128
  • 9
    Bagatell CJ, Heiman JR, Rivier JE, Bremner WJ. Effects of endogenous testosterone and estradiol on sexual behavior in normal young men. J Clin Endocrinol Metab 1994; 78: 7116
  • 10
    Anderson RA, Bancroft W, Wu FCW. The effects of exogenous testosterone on sexuality and mood in normal men. J Clin Endocrinol Metab 1982; 75: 15037
  • 11
    Bancroft I. Endocrinology of sexual function. Clin Obstet Gynecol 1980; 7: 25381
  • 12
    Kinsey AC, Pomeroy WB, Martin CE. Sexual Behavior in the Human Male. Philadelphia: WB Saunders, 1948
  • 13
    Pfeiffer E, Verwoerdt A, Wang HS. Sexual behavior in aged men and women. Arch General Psychiatry 1968; 19: 7538
  • 14
    Pfeiffer E, Verwoerdt A, Davis GC. Sexual behavior in middle life. Am J Psychiatry 1972; 128: 12627
  • 15
    Martin CE. Marital and sexual factors in relation to age, disease and longevity. In WirtRD, WinokurG, RoffM eds, Life History Research in Psychopathology. Vol IV. Minneapolis: University of Minnesota Press, 1975: 32647
  • 16
    Persson G. Sexuality in a 70-year-old urban population. J Psychosom Res 1980; 24: 33542
  • 17
    Drafta D, Schindler AE, Stroe E, Neagsu E. Age-related changes of plasma steroid in normal adult males. J Steroid Biochem 1982; 17: 6837
  • 18
    Baker HWG, Burger HG, DeKretser DM, Hudson B, O'Connors WC. Change in the pituitary-testicular system with age. Clin Endocrinol 1976; 5: 34955
  • 19
    Tenover JS, Matsumoto AM, Plymate SR, Bremmer WJ. The effects of aging in normal men on bioavailable testosterone and LH hormone secretion: Response to clomiphene citrate. J Clin Endocrinol Metab 1987; 65: 111826
  • 20
    Winters SJ, Troen P. Episodic LH secretion and the response of LH and FSH to LH-releasing hormone in aged men. Evidence for coexistent primary testicular insufficiency and an impairment in gonadotrophic secretion. J Clin Endocrinol Metab 1982; 55: 5605
  • 21
    Nankin AR, Calkins JH. Decreased bioavailable testosterone in aging normal and impotent men. J Clin Endocrinol Metab 1986; 63: 141825
  • 22
    Skakkebaek NE, Bancroft J, Davidson DW, Warner P. Androgen replacement with oral testosterone indecanoate in hypogonadal men: a double-blind controlled study. Clin Endocrinol 1981; 14: 4961
  • 23
    Kwan M, Greenleaf WJ, Mann J, Crapo L, Davidson J. The nature of androgen action on male sexuality: a combined laboratory/self-report study on hypogonadal men. J Clin Endocrinol Metab 1983; 57: 55762
  • 24
    Carani C, Zini D, Baldini A, Della Casa L, Ghizzani A, Marrama P. Effects of androgen treatment in impotent men with normal and low levels of free testosterone. Arch Sex Behav 1990; 19: 22334
  • 25
    Martin CE. Factors affecting sexual functioning in 60–79 year old married males. Arch Sex Behav 1981; 10: 399420
  • 26
    Hollander N, Hollander VT. The microdetermination of testosterone in human spermatic vein blood. J Clin Endocrinol Metab 1958; 8: 96671
  • 27
    Schiavi RC, Rehman J. Sexuality and aging. Urol Clin North Am 1995; 22: 71126
  • 28
    Greenstein A, Plymate SR, Katz PG. Visually stimulated erection in castrated men. J Urol 1995; 153: 6502
  • 29
    Davidson JM, Camargo CA, Smith ER. Effects of androgen on sexual behavior in hypogonadal men. J Clin Endocrinol Metab 1979; 48: 9558
  • 30
    Reilly CM, Stopper VS, Mills TM. Androgens modulate the alpha-adrenergic responsiveness of vascular smooth muscle in the corpus cavernosum. J Androl 1997; 18: 2631
  • 31
    Mills TM, Wiedmeir VT, Stopper VS. Androgen maintenance of erectile function in the rat penis. Biol Reprod 1992; 46: 3428
  • 32
    Chamness SL, Ricker DD, Crone JK et al. The effect of androgen on nitric oxide synthase in the male reproductive tract of the rat. Fertil Steril 1995; 63: 11017
  • 33
    Garban H, Marquez D, Cai L, Rajfer J, Gonalez-Cadavid NF. Restoration of normal adult penile erectile response in aged rats by long-term treatment with androgens. Biol Reprod 1995; 53: 136572
  • 34
    Lugg JA, Rajfer J, Gonzalez-Cadavid NF. Dihydrotestosterone is the active androgen in the maintenance of nitric oxide-mediated penile erection in the rat. Endocrinology 1995; 136: 1495501
  • 35
    Zvara P, Sioufi R, Schipper HM, Begin LR, Brock GB. Nitric oxide mediated erectile activity is a testosterone dependent event: a rat erection model. Int J Impot Res 1995; 7: 20919
  • 36
    Schirar A, Bonnefond C, Meusnier C, Devinoy E. Androgens modulate nitric oxide synthase messenger ribonucleic acid expression in neurons of the major pelvic ganglion in the rat. Endocrinology 1997; 138: 3093102
  • 37
    Penson DF, Ng C, Cai L, Rajfer J, Gonzalez-Cadavid NF. Androgen and pituitary control of penile nitric oxide synthase and erectile function in the rat. Biol Reprod 1996; 55: 56774
  • 38
    Lugg J, Ng C, Rajfer J, Gonzalez-Cadavid NF. Cavernosal nerve stimulation in the rat reverses castration-induced decrease in penile NOS activity. Am J Physiol 1996; 271: 35461

Authors

  1. Authors

H.S. Ahn, MD, PhD, Associate Professor.

C.M. Park, MD, Resident in Training.

S.W. Lee, MD, PhD, Associate Professor.

Abbreviations
ED

erectile dysfunction

IIEF

International Index of Erectile Function

SHBG

sex-hormone binding globulin

NO

nitric oxide.